Medical Management Strategies in Acute and Chronic Rhinosinusitis.

The Journal of Allergy and Clinical Immunology. in Practice
Seong H ChoRichard F Lockey

Abstract

Chronic rhinosinusitis, historically, has been considered to be caused by upper airway anatomical abnormalities. However, today that concept has changed, for it is now recognized as an inflammatory disorder of the nasal and sinus mucosa. Acute rhinosinusitis is usually caused by a viral infection, whereas chronic rhinosinusitis is a persistent and heterogeneous inflammatory disorder with increased expression of type 1, 2, or 17 cytokines in the nasal and sinus mucosa, similar to that which occurs in asthma. Exacerbations are caused by aeroallergens in the allergic individual and irritants, pollutants, and viral/bacterial infections in all subjects. It may be categorized by phenotypes, examples of which include chronic rhinosinusitis with nasal polyps or chronic rhinosinusitis without nasal polyps. Defined endotypes are based on underlying pathophysiological mechanisms. Knowledge of chronic rhinosinusitis endotypes will optimize management by employing targeted medical therapies. Understanding that rhinosinusitis is a heterogeneous inflammatory disease has led to the identification of a variety of different predisposing conditions, new medical treatment options, and the concept that rhinosinusitis is primarily a medical problem.

Citations

Sep 25, 2020·International Forum of Allergy & Rhinology·Brent A SeniorZachary M Soler
Nov 5, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nitish KhuranaJeremiah A Alt
Mar 7, 2021·The Journal of Allergy and Clinical Immunology·Di WuLuo Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

International Forum of Allergy & Rhinology
Timothy L Smith
The Journal of Allergy and Clinical Immunology. in Practice
Anita Trikha, Todd Kingdom
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
D L Morris
BMJ : British Medical Journal
Alison CarterSaiful Alam Hannan
Immunology and Allergy Clinics of North America
Glenis K Scadding
© 2021 Meta ULC. All rights reserved