PMID: 46053Jan 18, 1975

Medical manipulation of the ductus arteriosus

Lancet
R B ElliottJ M Neutze

Abstract

Prostaglandin E-1 was infused into two children with cyanotic congenital heart-disease where patency of the ductus arteriosus was necessary to maintain arterial oxygen saturation. With each infusion oxygen saturation rose, probably as a result of dilatation of the ductus. Administration of the non-specific antagonist of prostaglandin synthesis, indomethacin, to one patient was associated with a fall in arterial saturation. The prevention of ductus closure by p.g.E-1 infusions over the first few weeks of life is a possiblility.

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Related Concepts

Arterial Oxygen Saturation Measurement
Dioxygen
Entire Ductus Arteriosus
Diastolic Blood Pressure
Osmosin
Antagonist Muscle Action
Molecular Oxygen Saturation
Pathological Dilatation
Oxygen Saturation Measurement
Congenital Heart Defects

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