Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation.

International Journal of Cancer. Journal International Du Cancer
Greta R BuninAnna T Meadows

Abstract

Although ionizing radiation induces germline mutations in animals, human studies of radiation-exposed populations have not detected an effect. We conducted a case-control study of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation, to investigate gonadal radiation exposure of parents from medical sources before their child's conception. Parents of 206 cases from nine North American institutions and 269 controls participated; fathers of 184 cases and 223 friend and relative controls and mothers of 204 cases and 260 controls provided information in telephone interviews on their medical radiation exposure. Cases provided DNA for RB1 mutation testing. Of common procedures, lower gastrointestinal (GI) series conferred the highest estimated dose to testes and ovaries. Paternal history of lower GI series was associated with increased risk of retinoblastoma in the child [matched odds ratio (OR) = 3.6, 95% confidence interval (CI) = 1.2-11.2, two-sided p = 0.02], as was estimated total testicular dose from all procedures combined (OR for highest dose=3.9, 95% CI = 1.2-14.4, p = 0.02). Maternal history of lower GI series was also associated with increased risk (OR = 7.6, 95% CI = 2.8-20.7, p < 0.001) as was...Continue Reading

References

Aug 1, 1988·The Science of the Total Environment·A K Haque, I A Al-Affan
Dec 16, 1998·Australian and New Zealand Journal of Medicine·D HarrisonL Collins
Feb 11, 2000·Radiation Research·J L SchwartzA W Hsieb
Mar 27, 2001·Nature Reviews. Genetics·J F Crow
Oct 16, 2004·The British Journal of Radiology·M MazonakisN Gourtsoyiannis
Dec 13, 2006·Environmental Research·Ursula Eichenlaub-RitterFrancesca Pacchierotti
Feb 14, 2007·Environmental and Molecular Mutagenesis·Andrew J WyrobekJack B Bishop
Mar 19, 2008·Mutation Research·Aparecido Divino da CruzMaria Paula Curado

❮ Previous
Next ❯

Citations

Jul 31, 2012·Cancer Causes & Control : CCC·Julia E HeckBeate Ritz
Dec 12, 2012·Cancer Causes & Control : CCC·Greta R BuninMarilyn Tseng
Mar 19, 2013·Occupational and Environmental Medicine·Amir AbdolahiGreta R Bunin
Dec 2, 2014·Pediatric Clinics of North America·Carlos Rodriguez-GalindoDeborah VanderVeen
Jan 1, 2014·Brachytherapy·UNKNOWN American Brachytherapy Society - Ophthalmic Oncology Task Force. Electronic address: paulfinger@eyecancer.com, UNKNOWN ABS – OOTF Committee
May 30, 2015·Journal of Child Neurology·Michael V Ortiz, Ira J Dunkel
Aug 4, 2020·Pediatric Blood & Cancer·Omar ShakeelGreta R Bunin
Nov 1, 2013·Asia-Pacific Journal of Ophthalmology·Fairooz P ManjandavidaJerry A Shields
Jun 26, 2012·Environmental and Molecular Mutagenesis·Greta R BuninArupa Ganguly
Jun 3, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Philip J Lupo, Logan G Spector

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.