Medical therapy for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines

Chest
David B BadeschAmerican College of Chest Physicians

Abstract

Pulmonary arterial hypertension (PAH) is often difficult to diagnose and challenging to treat. Untreated, it is characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and death. The past decade has seen remarkable improvements in therapy, driven largely by the conduct of randomized controlled trials. Still, the selection of most appropriate therapy is complex, and requires familiarity with the disease process, evidence from treatment trials, complicated drug delivery systems, dosing regimens, side effects, and complications. This chapter will provide evidence-based treatment recommendations for physicians involved in the care of these complex patients. Due to the complexity of the diagnostic evaluation required, and the treatment options available, it is strongly recommended that consideration be given to referral of patients with PAH to a specialized center.

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·J S Stamler, J Loscalzo
Oct 1, 1992·The Journal of Clinical Investigation·M A CreagerJ P Cooke
Apr 1, 1992·Journal of the American College of Cardiology·B J SchraderS Rich
Jul 9, 1992·The New England Journal of Medicine·B W ChristmanJ E Loyd
Jan 1, 1992·British Journal of Clinical Pharmacology·E Bassenge
Apr 1, 1990·Trends in Pharmacological Sciences·J A Beavo, D H Reifsnyder
Dec 1, 1990·Circulation Research·X J GirerdM A Creager
Jan 1, 1986·European Journal of Clinical Pharmacology·W Krause, T Krais
Jan 1, 1986·Journal of the American College of Nutrition·L Zieve
Dec 1, 1987·Journal of the American College of Cardiology·B S EdwardsJ E Edwards
Jan 1, 1995·Life Sciences·S Das, K N Kumar
Sep 1, 1995·Progress in Cardiovascular Diseases·J Loscalzo, G Welch
Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·K G ThusuR H Steinhorn
Jun 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·P M Vanhoutte, C M Boulanger
Mar 1, 1995·Journal of Cardiovascular Pharmacology·G M Pieper, B A Peltier
Feb 1, 1995·Journal of the American College of Cardiology·J SandovalM E Furuya
Jan 26, 1995·Biochemical and Biophysical Research Communications·V VastaP Bruni
Jun 1, 1994·Cardiovascular Drugs and Therapy·W J Paulus
Dec 1, 1994·The American Journal of Cardiology·S H KuboM D Garr
Jan 1, 1994·Biology of the Neonate·R J VosatkaR R Trifiletti
Jun 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K G SmedstadD H Morison
Oct 1, 1993·Physiology & Behavior·L MilakofskyW H Vogel
Sep 1, 1993·American Heart Journal·H DrexlerH R Brunner
Jan 1, 1993·Annual Review of Medicine·T F LüscherG Noll
Jun 17, 1993·The New England Journal of Medicine·A GiaidD J Stewart
Jul 1, 1995·International Journal of Cardiology·J M Canty, T P Smith
Mar 1, 1996·Clinics in Chest Medicine·D E Schraufnagel, J M Kay
Dec 1, 1995·The European Respiratory Journal·N F Voelkel, R M Tuder

❮ Previous
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Citations

Aug 26, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Maria E CampianHanno L Tan
Mar 8, 2011·Internal and Emergency Medicine·Francesco MarongiuGualtiero Palareti
Feb 21, 2009·Current Atherosclerosis Reports·Aydin Uzunpinar, Mehmet Cilingiroglu
Jan 27, 2009·Current Gastroenterology Reports·Ravi P NayakGeorge M Matuschak
Apr 2, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mariko Harada-ShibaKazunori Kataoka
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Marc Humbert, Gérald Simonneau
Feb 28, 2007·Nature Clinical Practice. Rheumatology·James R Seibold
Jan 22, 2005·The New England Journal of Medicine·Anne-Margriet HuismanHenk C van Paassen
Aug 16, 2006·The Journal of Experimental Medicine·Brian S ZuckerbraunLeo E Otterbein
Jun 17, 2011·Cardiovascular Research·Martina DelbeckGeorges von Degenfeld
Mar 28, 2012·European Heart Journal·Irene M Lang, Raymond Benza
Sep 15, 2007·Critical Care Medicine·Roham T ZamanianAnn B Weinacker
Oct 21, 2006·Cardiology in Review·Teresa De Marco
Oct 6, 2005·Journal of Pediatric Gastroenterology and Nutrition·Ahmed LavingJoel E Lavine
Apr 17, 2010·Cardiology in Review·Joe R Anderson, James J Nawarskas
Jul 21, 2009·Current Opinion in Pediatrics·Alisa Limsuwan, Pongsak Khowsathit
Nov 20, 2008·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Aimee DoranBrett Goetz
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Steven H Abman
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary P Mullen
Jun 10, 2010·Southern Medical Journal·Vichaya ArunthariCharles D Burger
Aug 4, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Louise GandertonEli Gabbay
Oct 27, 2006·Heart·Astrid E LammersSheila G Haworth
Nov 19, 2005·Respiration; International Review of Thoracic Diseases·Raymond J Foley, Mark L Metersky
Mar 22, 2008·American Journal of Respiratory and Critical Care Medicine·Benjamin SztrymfMarc Humbert
Mar 5, 2008·American Journal of Respiratory and Critical Care Medicine·Marc Humbert
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Jason S FritzSteven M Kawut
Apr 2, 2009·BMC Cardiovascular Disorders·Jean-Frédéric VodozJean-François Cordier
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Rajendrakumar PatelSumir P Sahgal
May 1, 2005·Future Cardiology·Steeve ProvencherOlivier Sitbon
Jul 18, 2009·International Heart Journal·Takeyoshi KuniedaHitoshi Hishida
May 9, 2012·Drug Design, Development and Therapy·Olivier LambertNagesh Palepu
Nov 19, 2009·Drug Design, Development and Therapy·Brian Casserly, James R Klinger
Jan 1, 2009·Journal of Multidisciplinary Healthcare·Geoff StrangeEli Gabbay
Oct 7, 2010·Clinical Drug Investigation·Zeenat Safdar
Feb 27, 2008·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Akira Suwa
Oct 25, 2012·Current Cardiology Reviews·Lori A Walker, Peter M Buttrick
Sep 4, 2010·Annals of Pediatric Cardiology·Shreepal Jain, Balu Vaidyanathan
Nov 19, 2013·Pharmaceutical Patent Analyst·Dipesh BaradiaAmbikanandan Misra
Dec 18, 2009·Future Cardiology·Mantej K ChhinaSteven D Nathan

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