Medical therapy versus transurethral resection of the prostate (TURP) for the treatment of symptomatic benign prostatic enlargement (BPE): a cost minimisation analysis

World Journal of Urology
Niall F DavisA Tubaro

Abstract

A cost minimisation analysis compares the costs of different interventions' to ascertain the least expensive over time. We compared different prostate targeted drug treatments with TURP to identify the optimal cost saving duration of a medical therapy for symptomatic benign prostatic enlargement (BPE). The Evolution registry is a prospective, multicentre registry, conducted by the European Association of Urology Research Foundation (EAUrf) for 24 months in 5 European countries. Evolution was designed to register the management of symptomatic BPE in clinical practice settings in 5 European countries. Direct cost evaluation associated with prostate targeted medical therapies and TURP was also recorded and analysed. In total, 1838 men were enrolled with 1246 evaluable at 24 months. Medical therapies were more cost saving than TURP for treatment durations ranging from 2.9 to 70.4 years. Cost saving depended on both medication class and individual country assessed. Daily tamsulosin monotherapy was more cost saving than TURP for ≤ 13.9 years in Germany compared to ≤ 32.7 years in Italy. Daily finasteride monotherapy was more cost saving for ≤ 5.9 years in France compared to ≤ 36.9 years in Spain. Combination therapy was more cost sav...Continue Reading

References

Dec 19, 2003·The New England Journal of Medicine·John D McConnellUNKNOWN Medical Therapy of Prostatic Symptoms (MTOPS) Research Group
Nov 6, 2008·Clinical Interventions in Aging·Claus G Roehrborn, Raymond C Rosen
Nov 26, 2010·Current Opinion in Urology·R Daron Smith, Anup Patel
Mar 23, 2011·The Journal of Urology·Kevin T McVaryJohn T Wei
May 4, 2012·Drugs & Aging·Gillian M Keating
Nov 14, 2014·Current Opinion in Urology·Ingrid Schauer, Stephan Madersbacher
May 6, 2016·Nature Reviews. Disease Primers·Bilal ChughtaiSteven A Kaplan

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Citations

Jun 21, 2019·Current Urology Reports·Molly E DeWitt-FoyJames C Ulchaker
Mar 2, 2021·Scandinavian Journal of Urology·Erik SagenMarianne Månsson
Jul 16, 2021·Current Opinion in Urology·Maximilian PallaufLukas Lusuardi

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