Oct 18, 2011

Medical treatment overview: traditional and novel psycho-pharmacological and complementary and alternative medications

Current Opinion in Pediatrics
Evdokia Anagnostou, Robin L Hansen


Up to 35% of children and youth with autism spectrum disorder (ASD) receive at least one psychotropic medication. 50-70% of this population also receives biologically based complementary and alternative medicine (CAM). The data evaluating such practices are being reviewed. There are accumulating data to suggest that atypical antipsychotics and stimulants may be useful for the treatment of irritability and hyperactivity in children and youth with ASD. The data for the use of selective serotonin reuptake inhibitors are less promising. New avenues of pharmacologic research targeting molecular targets identified by genomics, animal models and neuropathology are being evaluated. Areas of interest include glutamate/gamma-aminobutyric acid systems, neuropeptides such as oxytocin, and immune dysfunction, among others. In the case of biologically based CAM, a few compounds have been shown to be well tolerated, although efficacy is still being evaluated, such as melatonin, certain vitamins, and omega 3 fatty acids. Others have safety concerns without demonstrated efficacy, such as chelation therapies. Accumulating data suggest a series of existing medications may be useful in ASD and large randomized clinical trials are necessary to eval...Continue Reading

  • References55
  • Citations7


Mentioned in this Paper

Immune System Diseases
Omega-3 Fatty Acids
Clinical Trials, Randomized
Alternative Medicine
Antipsychotic Agents
Recombinant Oxytocin

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here


Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research.

Related Papers

Journal of the American College of Cardiology
Stanley G Rockson
Lymphatic Research and Biology
Stanley G RocksonWendy Chaite
Annals of Plastic Surgery
Anne G WarrenSumner A Slavin
© 2020 Meta ULC. All rights reserved