Medical treatment update on pulmonary arterial hypertension

Therapeutic Advances in Chronic Disease
Cher Y Enderby, Charles Burger

Abstract

Pulmonary arterial hypertension is a chronic, progressive disease of the pulmonary vasculature resulting in poor outcomes if left untreated. The management of group 1 pulmonary arterial hypertension has included the use of prostanoids, phosphodiesterase-5 inhibitors, and endothelin receptor antagonists targeting the prostacyclin, endothelin-1, and nitric oxide pathways. Three new medications have been approved by the US Food and Drug Administration over the past couple of years. Macitentan is the newest endothelin receptor antagonist, riociguat is a soluble guanylate cyclase stimulator, and treprostinil diolamine is the first oral prostanoid. This review will focus on the key trials leading to their approval, special considerations for each medication, and their potential place in therapy. The use of combination therapy as initial therapy in pulmonary arterial hypertension will also be discussed.

References

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Citations

Mar 24, 2016·Journal of Managed Care & Specialty Pharmacy·Nicholas S HillCherilyn L Heggen-Peay
Feb 24, 2016·Expert Opinion on Drug Discovery·Yon K SungVinicio A de Jesus Perez
Dec 28, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Sergio Cadenas-MenéndezJosé Manuel Cifrián Martínez
Sep 5, 2021·Mayo Clinic Proceedings·Charles D BurgerRobert P Frantz

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