Medical Treatments for Acromegaly: A Systematic Review and Network Meta-Analysis

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Letícia Paula LeonartRoberto Pontarolo

Abstract

Acromegaly results from the hypersecretion of growth hormone. Because of the low incidence rates of this disease worldwide, few clinical trials evaluating drug treatments have been conducted. To conduct the first network meta-analysis simultaneously comparing all available drugs used in acromegaly treatment so as to provide more robust evidence in this field. A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Cochrane Collaboration recommendations (PROSPERO database under the registration number CRD42017059880). The electronic searches were conducted in PubMed (MEDLINE), Scopus, and Web of Science databases. Randomized controlled trials comparing any drug for the treatment of acromegaly head-to-head or versus placebo were included. Outcomes concerning the efficacy and safety of treatments were evaluated. The statistical analyses were performed using Aggregate Data Drug Information System version 1.16.8 (drugis.org, Groningen, The Netherlands). The initial search retrieved 2059 articles. Of these, 10 randomized controlled trials were included in a qualitative analysis and 7 in a quantitative analysis. The network meta-analysis for the efficacy outcome (number of ...Continue Reading

Citations

Feb 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nidan QiaoNicholas A Tritos
Aug 21, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Ewa OrlewskaKatarzyna Orlewska
May 24, 2020·Archives of Gynecology and Obstetrics·Meng JinYouguo Chen
Apr 17, 2020·Neuroendocrinology·Leticia P LeonartRoberto Pontarolo

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