Medication adherence and persistence in patients with autoimmune rheumatic diseases: a narrative review

Patient Preference and Adherence
Laura-Alexandra AnghelRadu Nicolae Oprean

Abstract

Several drugs are available for the treatment of autoimmune rheumatic diseases; however, their effectiveness may be negatively influenced by inappropriate adherence. Low adherence and persistence rates have a significant impact on patient quality of life and are associated with health-related expenses. To provide an up-to-date narrative review on treatment adherence and persistence rates, and discuss the factors that influence them, in patients with autoimmune rheumatic diseases. We searched the PubMed database for studies among patients with a diagnosis of rheumatoid arthritis (RA), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), or psoriatic arthritis (PsA), published from January 2015 to February 2017. Only studies with a well-defined measurement of adherence/persistence and those that carried out an evaluation of the influencing factors were included. Fifteen relevant studies that evaluated adherence and/or persistence were included. Adherence rates varied between 9.3% and 94%, and persistence rates between 23% and 80%. Most of the studies used one method to evaluate adherence or persistence (different questionnaire scores, proportion of days covered, and mean treatment duration). A high concordance was fou...Continue Reading

Citations

Jun 14, 2019·Expert Review of Clinical Immunology·Michael Ruberson Ribeiro da SilvaFrancisco de Assis Acurcio
Mar 2, 2019·Future Science OA·Michael Ruberson Ribeiro da SilvaFrancisco de Assis Acurcio
Feb 15, 2020·Nature Reviews. Rheumatology·Jasper C A Broen, Jacob M van Laar
Aug 23, 2020·International Journal of Environmental Research and Public Health·Motoyasu MiyazakiOsamu Imakyure
May 28, 2019·Yonsei Medical Journal·Ji Ho LeeYoo Seob Shin
Nov 27, 2019·Clinical Rheumatology·Clélia MonchablonThierry Lequerré
Feb 10, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Anne LohseValérie Devauchelle-Pensec
Jul 22, 2021·Clinical Nursing Research·Huda Al-NoumaniSathiya M Panchatcharam
Sep 30, 2021·Cardiology and Therapy·Konstantinos TsioufisJoris van Vugt
Dec 7, 2021·Frontiers in Medicine·Baptiste QuéréValérie Devauchelle-Pensec

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