Medication adherence to first-line antihypertensive drug class in a large Chinese population.

International Journal of Cardiology
Martin C S WongSian M Griffiths

Abstract

Suboptimal adherence to antihypertensive agents leads to adverse clinical outcomes. This study aims to evaluate the association between first-line antihypertensive drug class and medication adherence in a large Chinese population. All patients prescribed ≥ one antihypertensive drug in 2001-2003 and 2005 who have paid at least two consecutive clinic visits in the public healthcare system of Hong Kong were included. We excluded patients who have followed-up in the clinics for ≤ 30 days. Interval-based Proportion of Days Covered (PDC) was used to assess medication adherence. All patients were followed-up for up to 5 years. Binary logistic regression analysis was used to evaluate the factors associated with optimal adherence, defined as PDC ≥ 80%. From 147,914 eligible patients, 69.2% were adherent to the antihypertensive prescriptions. When compared with angiotensin converting enzyme inhibitors (ACEIs), patients initially prescribed α-blockers (adjusted odds ratio [AOR]=0.234, 95% C.I. 0.215-0.256), β-blockers (AOR=0.447, 95% C.I. 0.420, 0.477), thiazide diuretics (AOR=0.431 95% C.I. 0.399, 0.466) and calcium channel blockers (AOR=0.451, 95% C.I. 0.423, 0.481) were significantly less likely to be drug adherers. Angiotensin recepto...Continue Reading

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Citations

Dec 3, 2014·International Journal of Cardiology·Martin C S WongJoseph T F Lau
Dec 17, 2014·International Journal of Cardiology·Martin C S WongAndrew J S Coats
Dec 3, 2014·International Journal of Cardiology·Martin C S WongAndrew J S Coats
Feb 11, 2014·Journal of Advanced Nursing·Shiah-Lian ChenI-Chen Liao
May 12, 2016·Current Medical Research and Opinion·Yuji LiguoriMisako Hamamura
May 10, 2017·Journal of Comparative Effectiveness Research·Mary JandeStanley Mwita
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Apr 22, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shiori NishimuraHiroaki Miyata
Feb 20, 2020·International Journal of Behavioral Medicine·Caitlin LiddelowElizaveta Novoradovskaya

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Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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