Abstract
Suboptimal adherence to antihypertensive agents leads to adverse clinical outcomes. This study aims to evaluate the association between first-line antihypertensive drug class and medication adherence in a large Chinese population. All patients prescribed ≥ one antihypertensive drug in 2001-2003 and 2005 who have paid at least two consecutive clinic visits in the public healthcare system of Hong Kong were included. We excluded patients who have followed-up in the clinics for ≤ 30 days. Interval-based Proportion of Days Covered (PDC) was used to assess medication adherence. All patients were followed-up for up to 5 years. Binary logistic regression analysis was used to evaluate the factors associated with optimal adherence, defined as PDC ≥ 80%. From 147,914 eligible patients, 69.2% were adherent to the antihypertensive prescriptions. When compared with angiotensin converting enzyme inhibitors (ACEIs), patients initially prescribed α-blockers (adjusted odds ratio [AOR]=0.234, 95% C.I. 0.215-0.256), β-blockers (AOR=0.447, 95% C.I. 0.420, 0.477), thiazide diuretics (AOR=0.431 95% C.I. 0.399, 0.466) and calcium channel blockers (AOR=0.451, 95% C.I. 0.423, 0.481) were significantly less likely to be drug adherers. Angiotensin recepto...Continue Reading
References
Nov 1, 1989·Contraception
Jan 28, 1998·Clinical Therapeutics·J A Rizzo, W R Simons
Nov 30, 2000·Journal of Human Hypertension·R B SinghN Sarraf-Zadigan
May 15, 2003·JAMA : the Journal of the American Medical Association·Katharina Wolf-MaierFenicia Vescio
Nov 15, 2003·Lancet·Fiona Turnbull, UNKNOWN Blood Pressure Lowering Treatment Trialists' Collaboration
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
May 6, 2004·Journal of Hypertension·Jan A StaessenUNKNOWN Systolic Hypertension in Europe (Syst-Eur) Trial Investigators
May 17, 2005·Journal of Hypertension·Alberto Zanchetti
May 17, 2005·American Heart Journal·Ann M BorzeckiDan R Berlowitz
Jan 6, 2007·Journal of the American Board of Family Medicine : JABFM·William J ElliottDouglas Gause
Jan 9, 2007·The American Journal of Medicine·David SiegelJoy Meier
Jul 6, 2007·Journal of Human Hypertension·M Di MartinoE Degli Esposti
Sep 12, 2007·Blood Pressure·Giuseppe MansiaUNKNOWN European Society of Cardiology
Jun 27, 2008·BMC Health Services Research·Martin C S WongStewart W Mercer
Mar 31, 2009·Medical Care·Carolyn T ThorpeHayden B Bosworth
Oct 7, 2009·Circulation·Aram V Chobanian
Oct 7, 2009·Circulation·Giampiero MazzagliaLorenzo G Mantovani
Nov 10, 2009·Journal of Clinical Pharmacology·Martin C S WongSian M Griffiths
Jan 28, 2010·The American Journal of Medicine·Oded FriedmanUNKNOWN Canadian Hypertension Education Program Outcomes Research Taskforce
Jan 30, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Martin C S WongSian M Griffiths
Aug 10, 2010·Journal of Epidemiology and Community Health·M C S WongS M Griffiths
Mar 4, 2011·Journal of Clinical Pharmacy and Therapeutics·M C S WongS M Griffiths
Oct 5, 2011·Hypertension·Marie Krousel-WoodRichard N Re
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Citations
Sep 16, 2014·Current Medical Research and Opinion·Lin XieOnur Baser
Dec 3, 2014·International Journal of Cardiology·Martin C S WongJoseph T F Lau
Dec 17, 2014·International Journal of Cardiology·Martin C S WongAndrew J S Coats
Aug 19, 2014·International Journal of Cardiology·Kelvin K F TsoiSian M Griffiths
Dec 3, 2014·International Journal of Cardiology·Martin C S WongAndrew J S Coats
Feb 2, 2015·International Journal of Cardiology·Martin C S WongSian M Griffiths
Jan 15, 2015·International Journal of Cardiology·Candy D KangMartin C S Wong
May 15, 2015·International Journal of Cardiology·Martin C S WongSian M Griffiths
Oct 9, 2014·Journal of Clinical Pharmacology·Martin C S WongDonald E Morisky
Feb 11, 2014·Journal of Advanced Nursing·Shiah-Lian ChenI-Chen Liao
Jun 24, 2014·Environmental Pollution·Martin C S WongIgnatius T S Yu
Aug 13, 2013·International Journal of Cardiology·Martin C S WongSian M Griffiths
Nov 24, 2012·International Journal of Cardiology·Martin C S WongSian Griffiths
Jul 6, 2014·International Journal of Cardiology·Martin C S WongSian M Griffiths
Dec 4, 2014·PloS One·Marta Fernandez-AriasGerman Malaga
May 12, 2016·Current Medical Research and Opinion·Yuji LiguoriMisako Hamamura
Jul 1, 2016·International Journal of Cardiology·Martin C S WongAndrew J S Coats
Jul 10, 2016·International Journal of Cardiology·Martin SchulzMiriam Ude
Feb 2, 2017·PloS One·Thi-Phuong-Lan NguyenMaarten J Postma
May 10, 2017·Journal of Comparative Effectiveness Research·Mary JandeStanley Mwita
Aug 18, 2017·Therapeutic Advances in Chronic Disease·Alvin B OungJoseph J Saseen
Jun 24, 2015·Current Opinion in Lipidology·Martin C S WongHarry H X Wang
Apr 22, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shiori NishimuraHiroaki Miyata
Feb 20, 2020·International Journal of Behavioral Medicine·Caitlin LiddelowElizaveta Novoradovskaya
May 6, 2020·Vascular Health and Risk Management·Haleh HeizomiHaidar Nadrian
Oct 7, 2020·Journal of General Internal Medicine·Jing XiaoYong-Fu Yu
Jan 8, 2021·PloS One·Shokoufeh AalaeiLahya Afshari Saleh
Sep 4, 2020·Acta Biotheoretica·A Mhlanga, S Mushayabasa