Medication burden and inappropriate prescription risk among elderly with advanced chronic kidney disease

BMC Geriatrics
Clarisse Roux-MarsonP S P A Investigators

Abstract

Elderly patients with chronic kidney disease (CKD) frequently present comorbidities that put them at risk of polypharmacy and medication-related problems. This study aims to describe the overall medication profile of patients aged ≥75 years with advanced CKD from a multicenter French study and specifically the renally (RIMs) and potentially inappropriate-for-the-elderly medications (PIMs) that they take. This is a cross-sectional analysis of medication profiles of individuals aged ≥75 years with eGFR < 20 ml/min/1.73 m2 followed by a nephrologist, who collected their active prescriptions at the study inclusion visit. Medication profiles were first analyzed according to route of administration, therapeutic classification. Second, patients were classified according to their risk of potential medication-related problems, based on whether the prescription was a RIM or a PIM. RIMs and PIMs have been defined according to renal appropriateness guidelines and to Beer's criteria in the elderly. RIMs were subclassified by 4 types of category: (a) contraindication; (b) dose modification is recommended based on creatinine clearance (CrCl); (c) dose modification based on CrCl is not recommended but a maximum daily dose is mentioned, (d) no ...Continue Reading

References

Dec 22, 1994·The American Journal of Cardiology·M AparicioJ Sennesael
Nov 4, 1998·Postgraduate Medical Journal·N A Wong, H W Jones
Mar 17, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George R BailieRajiv Saran
Dec 15, 2006·British Journal of Clinical Pharmacology·Marie-Laure LarocheLouis Merle
Aug 3, 2007·Kidney & Blood Pressure Research·Bengt FellströmUNKNOWN AURORA Study Group
Aug 5, 2008·Current Medical Research and Opinion·Tsang-Bin TzengLi-Pin Kung
Sep 26, 2008·La Revue de médecine interne·M-L LarocheJ-P Charmes
Nov 14, 2008·Journal of the American Society of Nephrology : JASN·Olivier MoranneUNKNOWN NephroTest Study Group
Dec 26, 2008·JAMA : the Journal of the American Medical Association·Dima M QatoStacy Tessler Lindau
Oct 13, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aimun K AhmedA Meguid El Nahas
Aug 24, 2010·Advances in Chronic Kidney Disease·Katie E CardoneHarold J Manley
Feb 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gaëlle BretonBenedicte Stengel
Sep 29, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Davy TawadrousAmit X Garg
Apr 14, 2012·Diabetes Care·Yusuke SakaguchiYoshiharu Tsubakihara
Aug 4, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Evi V NaglerCarmine Zoccali
Oct 12, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Olivier MoranneUNKNOWN PSPA Study Investigators
Sep 11, 2013·Nature Reviews. Nephrology·Luis M Ruilope
Mar 29, 2014·Current Opinion in Nephrology and Hypertension·Matthew R Weir, Jeffrey C Fink
May 17, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kailin L HsuClarissa J Diamantidis
Sep 4, 2015·Disease-a-month : DM·Richard GargiuloEdgar Lerma
Oct 9, 2015·Journal of the American Geriatrics Society·UNKNOWN By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel
Oct 16, 2015·Medicine·Géraldine Leguelinel-BlacheAlbert Sotto
Oct 28, 2015·Journal of the American Geriatrics Society·Flora ChangMichael A Steinman
Apr 8, 2016·Nature Reviews. Cardiology·Gema Ruiz-HurtadoLuis M Ruilope
May 26, 2017·International Journal of Clinical Practice·Wubshet Hailu TesfayeSyed Tabish R Zaidi
Jul 20, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elizabeth SimonsenClaudio Rigatto
Oct 5, 2018·Drugs & Aging·Laura K TriantafylidisJulie M Paik
May 14, 2019·JAMA Internal Medicine·Kim H DeRhodes

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Citations

May 8, 2020·Journal of Clinical Medicine·Maria Antonietta BarbieriVincenzo Arcoraci
Oct 10, 2020·Seminars in Dialysis·Karumathil M Murali, Maureen Lonergan
Jun 3, 2021·International Journal of Molecular Sciences·Guido GembilloGianluca Trifirò
Oct 26, 2021·Frontiers in Pharmacology·Vincenzo ArcoraciUNKNOWN REPOSI investigators

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Clinical Trials Mentioned

NCT02910908

Software Mentioned

SAS

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