Medication-Induced Hyperlactatemia and Lactic Acidosis: A Systematic Review of the Literature

Pharmacotherapy
Zachary R SmithMegan A Rech

Abstract

Hyperlactatemia and lactic acidosis are two syndromes that are associated with morbidity and mortality. Medication-induced hyperlactatemia and lactic acidosis are diagnoses of exclusion and have the potential to be overlooked. The purposes of this systematic review are to identify published reports of medication-induced lactate level elevations to aid clinicians in diagnosing and comprehending the underlying mechanism of this rare adverse drug effect and to provide management strategies. The PubMed database was searched for case reports, case series, retrospective studies, and prospective studies describing cases of medication-induced lactate level elevation, including lactic acidosis and hyperlactatemia, published between January 1950 and June 2017. A standardized search strategy was used, and the articles identified underwent two rounds of independent evaluation by two reviewers to assess for inclusion. Articles were included if they described at least one patient older than 12 years with hyperlactatemia or lactic acidosis caused by a medication with United States Food and Drug Administration (FDA) approval and if alternative etiologies for an elevated lactate level were ruled out. Metformin and nucleoside/nucleotide reverse ...Continue Reading

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Citations

Feb 15, 2020·Critical Care Medicine·Ross Freebairn
Jan 2, 2020·Journal of Clinical Medicine·Alina G LiedtkePietro B Faré
Dec 18, 2020·Anesthesiology·Richard M Pino, Jaskaran Singh
Jan 14, 2021·BMC Pulmonary Medicine·Vorakamol PhoophiboonThitiwat Sriprasart

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