PMID: 32532720Jun 14, 2020Paper

Medication management and pharmacokinetic changes after bariatric surgery.

Canadian Family Physician Médecin De Famille Canadien
Sabrina Lorico, Blaine Colton

Abstract

To identify expected pharmacokinetic changes and provide practical recommendations for the medication management of chronic disease states after bariatric surgery. MEDLINE, EMBASE, PubMed, Scopus, and the Cochrane Library were searched. The search was limited to studies in human adults. Search terms included obesity, obese, bariatric surgery, gastric bypass, gastrectomy, gastric band, RYGB, roux-en-y, gastrointestinal absorption, medication absorption, drug absorption, bioavailability, dose adjust, drug monitoring, medication adjust, drug change, medication change, medication management, and medication dosing. Reference lists of original studies and reviews were also hand searched. Included studies were entered into PubMed and articles under the "Similar articles" heading were also reviewed. Only studies relevant to bariatric surgery types currently available in Canada (ie, Roux-en-Y gastric bypass, sleeve gastrectomy, or gastric banding) were included. Pharmacokinetic changes anticipated after bariatric surgery vary by surgery type. There are several guiding principles that might be applied to medication management regimens after bariatric surgery. Practice tips are also presented for medication management of specific chronic ...Continue Reading

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