Medication non-adherence in the elderly: how big is the problem?

Drugs & Aging
Carmel M Hughes

Abstract

Adherence to medication is one of the most intriguing and complex behaviours demonstrated by patients. Non-adherence to a therapeutic regimen may result in negative outcomes for patients and may be compounded in populations with multiple morbidities which require multiple drug therapy. Such a population is exemplified by the elderly. However, non-adherence may not be more prevalent in older patients and there is no consensus in the literature that age is a predictor of poor adherence. Indeed, older patients may deliberately choose not to adhere to medication (intentional non-adherence) to avoid adverse effects. Furthermore, many of the studies on adherence lack commonality in terms of how adherence is measured, the definition of an 'older' patient and the range of disease states which have been examined. Adherence may also be affected by access to medications which may be restricted by the use of formularies or insurance programmes. However, non-adherence may represent a greater risk in older people resulting in poor disease control which may be compounded with multiple morbidity and polypharmacy. A range of strategies have been implemented to try and improve adherence in this patient population. The use of forgiving drugs (tho...Continue Reading

References

Oct 1, 1992·Journal of Clinical Pharmacy and Therapeutics·L S Morris, R M Schulz
Oct 10, 1991·The New England Journal of Medicine·S B SoumeraiI Choodnovskiy
Aug 1, 1991·The Gerontologist·V O LeirerG M Pariante
Nov 1, 1989·The Medical Clinics of North America·R B Stewart, G J Caranasos
Aug 27, 1987·The New England Journal of Medicine·S B SoumeraiS Gortmaker
Nov 1, 1986·Journal of Clinical Pharmacology·R G FeldmanM C Lannon
Jan 1, 1985·Social Science & Medicine·P Conrad
Sep 19, 1985·The New England Journal of Medicine·R MayeuxL Cote
Jun 1, 1970·Circulation·M Markowitz
Jan 1, 1982·Circulation·R B HaynesD L Sackett
Jan 1, 1995·International Journal of Technology Assessment in Health Care·J L Donovan
May 1, 1995·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·M V Spiers, D M Kutzik
Jun 1, 1995·Journal of Behavioral Medicine·A J Christensen, T W Smith
Oct 9, 1993·Lancet·E C Wright
Feb 1, 1994·Journal of General Internal Medicine·J Melnikow, C Kiefe
Jan 1, 1993·Health Education Quarterly·M A RichardsonJ F Annegers
May 1, 1993·The Annals of Pharmacotherapy·M D MurrayJ C Darnell
Sep 1, 1993·Academic Medicine : Journal of the Association of American Medical Colleges·E V MorseP M Balson
Mar 1, 1993·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·M R DiMatteoW H Rogers
Oct 15, 1995·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·K M Powell, B Edgren
Jun 1, 1996·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·M De Young
Apr 1, 1996·Pharmacy World & Science : PWS·H S LauA J Porsius
Oct 31, 1997·The Gerontologist·R W MorrellM Martin
Jan 1, 1997·Geriatric Nephrology and Urology·R B CurtinP Sacksteder
Jul 29, 1998·The Annals of Pharmacotherapy·R E GrymonpreD S Sitar
Sep 16, 1998·Clinical Therapeutics·R Balkrishnan
Sep 25, 1998·Journal of Diabetes and Its Complications·M E Garay-SevillaL Jordán-Ginés
Feb 13, 1999·Journal of the American Geriatrics Society·D C ParkJ Bennett
Apr 8, 1993·Journal of Aging and Health·M BazarganV Hamm
Jun 16, 1999·The Annals of Pharmacotherapy·M B NicholJ C Sung
Aug 11, 2000·European Journal of Heart Failure·C M ClineL R Erhardt

❮ Previous
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Citations

Sep 29, 2006·International Journal of Geriatric Psychiatry·R Scott Mackin, Patricia A Areán
May 25, 2007·Fundamental & Clinical Pharmacology·Sarah N HilmerDavid G Le Couteur
Jul 31, 2007·Journal of the American Geriatrics Society·Kate L LapaneBrian J Quilliam
Jan 9, 2008·European Journal of Clinical Pharmacology·Shaojun ShiUlrich Klotz
Sep 8, 2010·Australian Journal of Primary Health·Caroline BulsaraJon E Emery
Mar 2, 2011·Cadernos de saúde pública·Tatiana Chama Borges LuzMaria Fernanda Lima-Costa
Jan 17, 2012·Expert Review of Neurotherapeutics·José Luis Molinuevo, Francisco Javier Arranz
Oct 26, 2012·Critical Reviews in Clinical Laboratory Sciences·Matthew D Linden, Huyen A Tran
May 31, 2012·Drugs & Aging·Eva TopinkováPierre-Olivier Lang
Oct 10, 2013·International Journal of Clinical Pharmacy·Rana Ahmed, Parisa Aslani
Feb 26, 2014·Drugs & Aging·Omar MukhtarStephen H D Jackson
Oct 14, 2014·The Journal of Clinical Hypertension·Andrea D BoanDaniel T Lackland
Feb 21, 2016·The Cochrane Database of Systematic Reviews·Mikkel Christensen, Andreas Lundh
May 31, 2017·International Journal of Clinical Pharmacy·Edeltraut KrögerLine Guénette
Jan 9, 2019·Neurourology and Urodynamics·Claire HentzenPhilippe Manceau
Jan 13, 2019·International Journal of Environmental Research and Public Health·Chau Quy NgoRoger C M Ho
Mar 19, 2019·Expert Opinion on Drug Metabolism & Toxicology·L E J PeetersJ Versmissen
Aug 23, 2019·Journal of the American Geriatrics Society·Green C ChungTaeho Greg Rhee
Jan 2, 2020·International Journal of Environmental Research and Public Health·Daniel GomesFátima Roque
Apr 6, 2006·Western Journal of Nursing Research·Mary Jayne Johnson, Sandra Rogers
Sep 26, 2007·Current Medical Research and Opinion·Gary Small, Bruno Dubois
Oct 6, 2007·Wiener medizinische Wochenschrift·Rudolf SchoberbergerMichael Kunze
Feb 18, 2009·Drugs & Aging·Jacquelyn L Bainbridge, J Mark Ruscin
May 9, 2007·Pharmacoepidemiology and Drug Safety·Marie HudsonLouise Pilote
Sep 14, 2007·Scandinavian Journal of Urology and Nephrology·Magnus LindbergBjörn Wikström
Jul 26, 2011·Current Medical Research and Opinion·Stephen BruntonAnthony H Barnett
Jan 5, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F ValldeoriolaUNKNOWN ADHESON Study Group
Mar 4, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P N SambrookJ M Simpson
May 31, 2011·Age and Ageing·Denis O'Mahony, Marie N O'Connor
Aug 11, 2012·Journal of General Internal Medicine·Anastasia SofianouAlex D Federman
Nov 8, 2013·Drugs & Aging·Anna N MillarCristín Ryan
Mar 1, 2013·Journal of Gerontological Nursing·Judith A ErlenFengyan Tang

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