Medication persistence for psoriatic arthritis in a Brazilian real-world setting

Future Science OA
Michael Ruberson Ribeiro da SilvaFrancisco de Assis Acurcio

Abstract

To evaluate the persistence of biological (TNF inhibitor [anti-TNF]) and synthetic (conventional synthetic disease-modifying antirheumatic drugs [csDMARDs]) antirheumatic agents for psoriatic arthritis and their associated factors. A historical cohort was developed. Persistence and associated factors were evaluated at 6 and 12 months. A total of 161 patients were included. The anti-TNF treatment presented higher persistence as compared with csDMARDs at 6 (83.4 vs 50.8%; p < 0.05) and 12 months (66.4 vs 35.6%; p < 0.05). From anti-TNFs, adalimumab and etanercept presented similar persistence, along with leflunomide and methotrexate among the csDMARDs. The factors associated with non-persistence with regard to anti-TNF agents were female sex and use of infliximab. Anti-TNF agents are important therapeutic alternatives and present lower rates of discontinuation as compared with csDMARDs.

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Citations

Jun 14, 2019·Expert Review of Clinical Immunology·Michael Ruberson Ribeiro da SilvaFrancisco de Assis Acurcio
Jan 22, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Michael Ruberson Ribeiro da SilvaFrancisco De Assis Acurcio
Jan 8, 2021·Rheumatology Advances in Practice·Kirk GealeElke Theander
Aug 15, 2021·Value in Health Regional Issues·Felipe A MoraesJuliana Alvares-Teodoro

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