Medication-related osteonecrosis of the jaw: Surgical or non-surgical treatment?

Oral Diseases
Gianfranco FaviaEugenio Maiorano

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a severe side effect of antiresorptive (bisphosphonates and denosumab) and anti-angiogenic therapy used in the management of oncologic and, less frequently, osteoporotic patients. While there is good international agreement on the diagnostic and staging criteria of MRONJ and the cessation of antiresorptive/anti-angiogenic treatments, the gold standard of treatment is still controversial, in particular between non-surgical and surgical approaches. The former usually includes antiseptic mouth rinse, cyclic antibiotic therapy, low-level laser therapy and periodic dental checks; the latter consists of surgical necrotic bone removal. The purpose of this retrospective study was to describe the therapeutic approaches and outcomes of 131 lesions from 106 MRONJ patients treated at the Policlinic of Bari. Non-surgical treatments were chosen for 24 lesions that occurred in 21 patients who, due to comorbidities and/or the impossibility of stopping oncologic therapies, could not undergo surgical treatment. As to the outcome, all the surgically treated lesions (107) showed complete healing, with the exception of 13.5% of the lesions, all of which were stage III, which did not completely ...Continue Reading

References

Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
Jul 22, 2008·Head & Neck·Arno WutzlGabriele Millesi
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Eric R Carlson, John D Basile
Oct 1, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paolo VescoviSamir Nammour
Jun 16, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·John J FreibergerClaude A Piantadosi
Jul 22, 2014·International Journal of Dentistry·Pelagia I MeleaEvangelos Terpos
Sep 23, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroFelice O'Ryan
Dec 17, 2014·Clinical Oral Investigations·Petra RuganiNorbert Jakse
Sep 1, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Waldemar ReichAlexander Walter Eckert
Sep 16, 2015·The American Journal of Case Reports·Gianfranco FaviaEugenio Maiorano
Jun 7, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Saki HayashidaMasahiro Umeda

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Citations

Sep 11, 2019·Head & Neck·Elen de Souza TolentinoMariliani C da Silva
Feb 15, 2020·Oral and Maxillofacial Surgery·Gustavo Antonio Correa MomessoEduardo Piza Pellizzer
Jun 27, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Vittorio MoraschiniJosé de Albuquerque Calasans-Maia
Apr 24, 2019·BioMed Research International·Milan PetrovicVitomir Konstantinovic
Nov 24, 2020·Oral and Maxillofacial Surgery·Stefan MollChristoph Klingelhöffer
Oct 23, 2020·International Journal of Oral Science·Lina HeYumei Niu
Mar 17, 2021·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Junho JungYong-Dae Kwon
May 24, 2021·Brazilian Journal of Otorhinolaryngology·Onur ŞahinOnur Odabaşı

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