Medications as a source of paraben exposure

Reproductive Toxicology
Laura E DodgeRuss Hauser

Abstract

Parabens are used as antimicrobial excipients in some pharmaceuticals. Parabens may adversely affect reproduction. Determine whether paraben-containing medication contributes to high urinary paraben concentrations. Individuals at a fertility clinic provided multiple urine samples during evaluation/treatment and reported 24-h use of medications and personal care products (PCP). Repeated measures models compared specific gravity-adjusted urinary methyl, propyl, and butyl paraben concentrations between samples "exposed" and "unexposed" to paraben-containing medication. Eleven participants contributed 12 exposed and 45 unexposed samples, among which paraben concentrations did not differ. Use within 7h was associated with 8.7-fold and 7.5-fold increases in mean methyl (P=0.11) and propyl (P=0.10) paraben concentrations, respectively, after adjusting for PCP use. However, these associations decreased to 1.3-fold (P=0.76) and 2.6-fold (P=0.34), respectively, after removal of one influential individual. Paraben-containing medications contributed to higher urinary paraben concentrations within hours of use.

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Citations

Jan 5, 2016·Environmental Science & Technology·Wei Wang, Kurunthachalam Kannan
Dec 15, 2015·Fertility and Sterility·Lidia Mínguez-AlarcónUNKNOWN EARTH Study Team
Jul 23, 2016·Environmental Toxicology·Marina T GuerraW G Kempinas
Mar 21, 2017·Environmental Science & Technology·Mandy FisherTye E Arbuckle
Jan 19, 2017·Dermatitis : Contact, Atopic, Occupational, Drug·Kevin M BeeneMargo J Reeder
Jun 11, 2016·Environmental Health Perspectives·Melissa M SmarrGermaine M Buck Louis
Dec 21, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Anthony F FranswayMargo J Reeder
Dec 21, 2018·Dermatitis : Contact, Atopic, Occupational, Drug·Anthony F FranswayJames A Yiannias
Jul 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Matthew GencoRobert M Sargis
Jan 17, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anthony F FranswayJames A Yiannias
Aug 9, 2020·Journal of Applied Toxicology : JAT·Adyeni Barajas-SalinasFahiel Casillas
Feb 12, 2019·Asia Pacific Allergy·Motoko Mitsui-IwamaYukihiro Ohya
Jan 17, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anthony F FranswayMargo J Reeder
Nov 26, 2020·International Wound Journal·Eveline Torfs, Gilles Brackman
Nov 2, 2018·Environmental Research·Andrea BellaviaUNKNOWN EARTH Study Team
Apr 13, 2020·International Journal of Hygiene and Environmental Health·Dorothy NakiwalaUNKNOWN SEPAGES study group
Apr 7, 2018·Environmental Research·Laura E DodgeRuss Hauser
Jul 26, 2017·Talanta·Lucie Kolatorova SosvorovaRichard Hampl
Jul 23, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Zvonimir PetricIrena Žuntar
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Jul 30, 2021·Environmental Research·Hossein ArfaeiniaZahra Asadgol
Jan 11, 2020·The Science of the Total Environment·Aijing LiGuibin Jiang

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