Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis

Journal of the American Geriatrics Society
Edwin C K TanKristina Johnell

Abstract

To assess and quantify the risk of drug-induced dry mouth as a side effect in older people. Systematic review and metaanalysis. A search of the literature was undertaken using Medline, Embase, Cochrane, Web of Science, and PubMed from 1990 to 2016. Older people (aged ≥60) who participated in intervention or observational studies investigating drug use as an exposure and xerostomia or salivary gland hypofunction as adverse drug outcomes. Two pairs of authors screened titles and abstracts of studies for relevance. Two authors independently extracted data, including study characteristics, definitions of exposure and outcome, and methodological quality. For the metaanalyses, random-effects models were used for pooling the data and I2 statistics for exploring heterogeneity. Of 1,544 potentially relevant studies, 52 were deemed eligible for inclusion in the final review and 26 in metaanalyses. The majority of studies were of moderate methodological quality. In the intervention studies, urological medications (odds ratio (OR) = 5.91, 95% confidence interval (CI) = 4.04-8.63; I2  = 62%), antidepressants (OR = 4.74, 95% CI = 2.69-8.32, I2  = 21%), and psycholeptics (OR = 2.59, 95% CI = 1.79-3.95, I2  = 0%) were significantly associated ...Continue Reading

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Citations

May 7, 2020·Journal of Dental Research·H WanP K Sharma
May 18, 2020·Journal of Alzheimer's Disease : JAD·Edwin C K TanGunilla Sandborgh-Englund
Dec 26, 2018·European Journal of Oral Sciences·Anne N ÅstrømSven Ordell
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Feb 14, 2021·International Journal of Environmental Research and Public Health·Shiho MorishitaHirohiko Hirano
Jan 23, 2021·International Journal of Environmental Research and Public Health·Ewa Pająk-ŁysekJoanna Zarzecka
Jan 26, 2021·Journal of Multidisciplinary Healthcare·Katharina HomannSusanne Schiek
Feb 18, 2021·Clinical Oral Investigations·Makiko KawamotoHiroshi Kurita
Mar 30, 2021·Oral Diseases·Edwin C K TanGunilla Sandborgh-Englund
Jan 14, 2020·Journal of the American Medical Directors Association·Laurie E DaviesBarbara Hanratty
Jul 19, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Maram BawazirIndraneel Bhattacharyya
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Oct 16, 2021·Scientific Reports·Mara-Zoe HummelsheimAnna Greta Barbe

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