Medications that cause weight gain and alternatives in Canada: a narrative review

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Sean WhartonRebecca Ag Christensen

Abstract

The cause of the obesity epidemic is multifactorial, but may, in part, be related to medication-induced weight gain. While clinicians may strive to do their best to select pharmacotherapy(ies) that has the least negative impact on weight, the literature regarding the weight effects of medication is often limited and devoid of alternative therapies. Antipsychotics, antidepressants, antihyperglycemics, antihypertensives and corticosteroids all contain medications that were associated with significant weight gain. However, there are several medication alternatives within the majority of these classes associated with weight neutral or even weight loss effects. Further, while not all of the classes of medication examined in this review have weight-favorable alternatives, there exist many other tools to mitigate weight gain associated with medication use, such as changes in dosing, medication delivery or the use of adjunctive therapies. Medication-induced weight gain can be frustrating for both the patient and the clinician. As the use of pharmaceuticals continues to increase, it is pertinent for clinicians to consider the weight effects of medications prior to prescribing or in the course of treatment. In the case where it is not fe...Continue Reading

Citations

Jul 2, 2020·American Journal on Intellectual and Developmental Disabilities·Laura St JohnJohn Cairney
Nov 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nida Siddiqi, Ibrahim F Shatat
Oct 7, 2020·Obesity·Hartej GillRoger S Mcintyre
Aug 26, 2020·The Journal of Biological Chemistry·Dong Young KimHyae Gyeong Cheon
Feb 1, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Nicholas C KolinskyRichard F Lockey
Mar 3, 2021·Surgical Endoscopy·Dimitrios I AthanasiadisDimitrios Stefanidis
Apr 13, 2021·The American Journal of Gastroenterology·Pichamol Jirapinyo, Christopher C Thompson

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Methods Mentioned

BETA
pharmacotherapy
pharmacotherapies

Software Mentioned

Contrave

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