Medicinal benefits of Nigella sativa in bronchial asthma: A literature review

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society
Abdulrahman KoshakMichael Heinrich

Abstract

Nigella sativa L. (NS) seeds, known as black seed, is a spice and a traditional herbal medicine used in various diseases including bronchial asthma. This review aimed to assess the studies supporting the medicinal use of NS in asthma and to highlight future research priorities. Various medical databases were searched for the effects of NS and its active secondary metabolites in asthma inflammation and outcomes. There were fourteen preclinical studies describing multiple effects of NS in animal or cellular models of asthma including bronchodilation, anti-histaminic, anti-inflammatory, anti-leukotrienes and immunomodulatory effects. Furthermore, seven clinical studies showed improvements in different asthma outcomes including symptoms, pulmonary function and laboratory parameters. However, often these studies are small and used ill-defined preparations. In conclusion, NS could be therapeutically beneficial in alleviating airway inflammation and the control of asthma symptoms, but the evidence remains scanty and is often based on poorly characterised preparations. Accordingly, well-designed large clinical studies using chemically well characterised NS preparation are required.

Citations

Aug 22, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maryam MolaieShima Afshar
Jul 30, 2019·Journal of Food Biochemistry·Ayed Dera, Prasanna Rajagopalan
Oct 14, 2020·Phytotherapy Research : PTR·Mohammad Nazrul IslamMd Jamal Uddin
Nov 14, 2020·Journal of Ethnopharmacology·Jun-Xi LiuJun Liang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael HeinrichVafa Amirkia
May 13, 2021·Drug Design, Development and Therapy·Osama A BadaryRajiv Tikamdas
Jun 3, 2021·International Journal of Environmental Research and Public Health·Leen A AldwihiOmar A Almohammed

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Methods Mentioned

BETA
Bronchoalveolar

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Scopus
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