Medicinal carbon tablets for treatment of acetaminophen intoxication: adsorption characteristics of medicinal carbon powder and its tablets

Chemical & Pharmaceutical Bulletin
Kenta YamamotoYoshiharu Machida

Abstract

Adsorption characteristics of medicinal carbon powder (JP 14) for acetaminophen were examined at 37 degrees C using conventional incubation in an attempt to obtain an effective oral dosage form. Hydroxypropyl cellulose (HPC) and maltitol (MT), being able to act as a binding agent, were tested as additives. Tablets of medicinal carbon were produced by the wet granulation method. The rate and extent of adsorption of the medicinal carbon powder were roughly similar in water, JP 14 1st fluid (pH 1.2) and JP 14 2nd fluid (pH 6.8). The relationship between concentrations of free and adsorbed acetaminophen indicated that the adsorption followed the Langmuir mode. The maximal adsorption of acetaminophen in water was 0.219 g per gram medicinal carbon powder, little influenced by the addition of MT, but slightly reduced by the addition of HPC. The tablet prepared using MT as a binding agent displayed a favorable hardness and adequate disintegration time. The tablet showed good adsorption potential for acetaminophen, though the adsorption rate and extent of the tablet were reduced to some extent as compared with powder.

References

Apr 1, 1977·Journal of Pharmaceutical Sciences·C A BainbridgeW D Walking
Jan 1, 1975·Biomaterials, Medical Devices, and Artificial Organs·R A Van WagenenJ D Andrade
Jul 1, 1990·The Journal of Emergency Medicine·Y Amitai, Y Degani
Jan 1, 1990·Journal of Toxicology. Clinical Toxicology·R F Fricke, J Jorge
Aug 1, 1970·Pediatric Clinics of North America·A L Picchioni
Aug 1, 1997·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·M KodamaT Tani
Sep 1, 2000·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·A K AlegakisV Liakou
Jun 7, 2002·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Takeo NakamuraSeiki Tanada
Jan 27, 2004·The Annals of Pharmacotherapy·Chie TanakaYasufumi Sawada
Oct 30, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael MichaelMalcolm J Moore
May 10, 2005·Clinical Therapeutics·Chu-Lin TsaiPhilip D Walson

❮ Previous
Next ❯

Citations

Oct 6, 2009·Chemical & Pharmaceutical Bulletin·Kenta YamamotoYoshiharu Machida
Apr 23, 2010·Chemical & Pharmaceutical Bulletin·Yoko SakudaYoshiharu Machida
Oct 17, 2009·Drug Development and Industrial Pharmacy·Masakazu MiyachiYoshiharu Machida
Sep 1, 2006·International Journal of Pharmaceutics·Kenta YamamotoYoshiharu Machida
Apr 6, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Akihiko ItoYoshiharu Machida
Aug 24, 2021·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Lotte C G HoegbergSophie Gosselin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.