Medicinal fungi: a source of antiparasitic secondary metabolites

Applied Microbiology and Biotechnology
Juliana LenziLorena Benathar Ballod Tavares

Abstract

Regions with a tropical climate are frequently affected by endemic diseases caused by pathogenic parasites. More than one billion people worldwide are exposed directly to tropical parasites. The literature cites several antiparasitic metabolites obtained from medicinal plants or via synthetic pathways. However, fungi produce a diversity of metabolites that play important biological roles in human well-being. Thus, they are considered a potential source of novel natural agents for exploitation in the pharmaceutical industry. In this brief review article, we will provide an overview of the current situation regarding antiparasitic molecules derived from filamentous fungi, in particular, those which are effective against protozoan parasites, such as Plasmodium, Trypanosoma, and Leishmania, vectors of some neglected tropical diseases. Diseases and parasitic agents are described and classified, and the antiparasitic properties of natural compounds produced by the fungi of the phyla Basidiomycota and Ascomycota are reviewed herein, in order to explore a topic only sparsely addressed in the scientific literature.

References

Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·S J Darkin-RattrayD M Schmatz
Dec 20, 2000·Antimicrobial Agents and Chemotherapy·G NagarajH Balaram
Jan 9, 2001·Clinical Microbiology Reviews·T B Gardner, D R Hill
Jul 16, 2002·Memórias do Instituto Oswaldo Cruz·Susana Muelas-SerranoAlicia Gomez-Barrio
May 24, 2003·Journal of Natural Products·Palangpon KongsaereeSuthep Wiyakrutta
Jun 12, 2003·Parasitology International·Yoshisada YabuNobuo Ohta
Aug 26, 2003·Parasitology Research·O KayserS L Croft
Nov 18, 2005·Parasitology International·Yoshisada YabuNobuo Ohta
Nov 29, 2005·Journal of Natural Products·Vatcharin RukachaisirikulRapheephat Suvannakad
Dec 3, 2005·Nature Reviews. Microbiology·Nancy P KellerJoan W Bennett
Jan 19, 2006·Clinical Microbiology Reviews·Simon L CroftAlan H Fairlamb
Apr 19, 2006·Phytotherapy Research : PTR·Edwin CorreaFernando Echeverri
Apr 29, 2006·Journal of Natural Products·Jiraporn ThongtanMasahiko Isaka
Nov 15, 2008·Journal of Natural Products·Sergio Martínez-LuisLuis Cubilla-Rios
Jan 6, 2009·The Journal of Eukaryotic Microbiology·Jitender P Dubey
Jan 20, 2009·Mini Reviews in Medicinal Chemistry·Bhuwan B MishraVinod K Tiwari
Mar 12, 2009·Endocrine, Metabolic & Immune Disorders Drug Targets·M Novak, V Vetvicka
Jul 28, 2009·Experimental Parasitology·Jean-François Rossignol
Aug 12, 2009·Journal of Natural Products·Primmala KhumkomkhetKasem Soytong
Apr 14, 2010·Journal of Natural Products·Michael AdamsMatthias Hamburger
Jul 8, 2010·Journal of Global Infectious Diseases·Angela Clem
Aug 24, 2010·International Journal of Antimicrobial Agents·Jose A Ruiz Postigo
Nov 23, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E M Souza-FagundesO A Martins-Filho
Jan 18, 2011·Natural Product Reports·Laura BarsantiPaolo Gualtieri
May 26, 2011·Expert Review of Anti-infective Therapy·Paulo M M GuedesJoão S Silva
May 27, 2011·American Journal of Botany·Meredith Blackwell
Jul 5, 2011·Parasitology International·Diogo G ValadaresEduardo A F Coelho
Aug 19, 2011·Organic Letters·Masahiko IsakaThitiya Boonpratuang
Oct 12, 2011·Journal of Natural Products·Damien LacroixBernard Bodo
Nov 16, 2011·Phytotherapy Research : PTR·Angel Ramos-LigonioAngel Trigos
Mar 24, 2012·Journal of Medicinal Chemistry·Erika IzumiCelso Vataru Nakamura
Mar 24, 2012·Journal of Ethnopharmacology·Habib GanfonJoëlle Quetin-Leclercq
Nov 2, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael Wink
Jan 3, 2013·Phytochemistry·Masahiko IsakaRattaket Choeyklin
Feb 8, 2013·Nature Medicine·Louis H MillerThomas E Wellems
Apr 13, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Coreen M BeaumierMaria Elena Bottazzi
May 1, 2013·Veterinary Parasitology·Paul R Torgerson

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Citations

Nov 12, 2019·Biotechnology and Applied Biochemistry·Tania Maria CostaDébora de Oliveira
Dec 15, 2020·PeerJ·Guodong NiuJun Li
Sep 28, 2020·Pharmacology & Therapeutics·Anutthaman ParthasarathyKarunakaran Kalesh

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Methods Mentioned

BETA
column chromatography

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