Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy

Oncotarget
Artem BlagodatskiVladimir L Katanaev

Abstract

Medicinal mushrooms have been used throughout the history of mankind for treatment of various diseases including cancer. Nowadays they have been intensively studied in order to reveal the chemical nature and mechanisms of action of their biomedical capacity. Targeted treatment of cancer, non-harmful for healthy tissues, has become a desired goal in recent decades and compounds of fungal origin provide a vast reservoir of potential innovational drugs. Here, on example of four mushrooms common for use in Asian and Far Eastern folk medicine we demonstrate the complex and multilevel nature of their anticancer potential, basing upon different groups of compounds that can simultaneously target diverse biological processes relevant for cancer treatment, focusing on targeted approaches specific to malignant tissues. We show that some aspects of fungotherapy of tumors are studied relatively well, while others are still waiting to be fully unraveled. We also pay attention to the cancer types that are especially susceptible to the fungal treatments.

References

Mar 1, 1996·Phytochemistry·A C KellerK Hostettmann
Oct 3, 2000·Phytochemistry·J RöseckeW A König
Sep 23, 2003·Biotechnology Advances·Jian Cui, Yusuf Chisti
Feb 28, 2004·Journal of Natural Products·Jordan K Zjawiony
Mar 23, 2004·Current Medicinal Chemistry·Robert van Der HeijdenRobert Verpoorte
Jan 19, 2008·World Journal of Gastroenterology : WJG·Myung-Ja YounRaekil Park
Apr 5, 2008·European Journal of Medicinal Chemistry·Sayaka TajiReiko Tanaka
Nov 3, 2010·International Journal of Oncology·Jiahua Jiang, Daniel Sliva
Nov 12, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hailing LuMary L Disis
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 27, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Filipa S ReisIsabel C F R Ferreira
Sep 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hailing LuLeanna J Standish
May 16, 2012·Anti-cancer Agents in Medicinal Chemistry·Tongtong XuJoshua D Lambert
Jun 16, 2012·ISRN Oncology·Carolyn J TorkelsonLeanna J Standish
Jun 6, 2013·Journal of Complementary & Integrative Medicine·Md Asaduzzaman KhanMohammad Mijanur Rahman
Dec 5, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jing-Yang WongVikineswary Sabaratnam
Feb 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hung-Tsung WuChih-Jen Chang
Mar 19, 2014·Journal of Ethnopharmacology·Guang LiGuishan Tan
Apr 20, 2014·Journal of Ethnopharmacology·Alexander N ShikovMichael Heinrich
May 3, 2014·Journal of Ethnopharmacology·Ulrike GrienkeJudith M Rollinger

❮ Previous
Next ❯

Citations

Feb 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xun SongChristine E Salomon
Nov 22, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elisa RodaPaola Rossi
Jan 12, 2021·Frontiers in Pharmacology·Michael JeitlerChristian S Kessler
Jan 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mehreen Zeb, Chow H Lee
Feb 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sachchida Nand RaiM P Singh
Apr 4, 2021·Journal of Fungi·Vaclav VetvickaTatiana A Korolenko
Jul 23, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Mateusz WinderJerzy Chudek
Jun 26, 2021·Journal of Food Biochemistry·Sandipta GhoshKrishnendu Acharya
Dec 11, 2021·Journal of Food Biochemistry·Jackson IsharaJohn Kinyuru

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
flow cytometry
xenografts
surgical resection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Evidence-based Complementary and Alternative Medicine : ECAM
Ulrike LindequistLeo Van Griensven
© 2022 Meta ULC. All rights reserved