Medicinal Plants Qua Glucagon-Like Peptide-1 Secretagogue via Intestinal Nutrient Sensors

Evidence-based Complementary and Alternative Medicine : ECAM
Ki-Suk Kim, Hyeung-Jin Jang

Abstract

Glucagon-like peptide-1 (GLP-1) participates in glucose homeostasis and feeding behavior. Because GLP-1 is rapidly inactivated by the enzymatic cleavage of dipeptidyl peptidase-4 (DPP4) long-acting GLP-1 analogues, for example, exenatide and DPP4 inhibitors, for example, liraglutide, have been developed as therapeutics for type 2 diabetes mellitus (T2DM). However, the inefficient clinical performance and the incidence of side effects reported on the existing therapeutics for T2DM have led to the development of a novel therapeutic strategy to stimulate endogenous GLP-1 secretion from enteroendocrine L cells. Since the GLP-1 secretion of enteroendocrine L cells depends on the luminal nutrient constituents, the intestinal nutrient sensors involved in GLP-1 secretion have been investigated. In particular, nutrient sensors for tastants, cannabinoids, and bile acids are able to recognize the nonnutritional chemical compounds, which are abundant in medicinal plants. These GLP-1 secretagogues derived from medicinal plants are easy to find in our surroundings, and their effectiveness has been demonstrated through traditional remedies. The finding of GLP-1 secretagogues is directly linked to understanding of the role of intestinal nutrie...Continue Reading

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Citations

Apr 14, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·In-Seung LeeHyeung-Jin Jang
Aug 15, 2018·Current Diabetes Reports·Zeinab Nazarian-SamaniMahmoud Rafieian-Kopaei
Oct 18, 2019·JCI Insight·Ki-Suk KimDarleen A Sandoval
Dec 11, 2020·Critical Reviews in Food Science and Nutrition·Ivan Chan-ZapataMaira Rubí Segura-Campos
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aisha Musaazi Sebunya NakittoAnika E Wagner
May 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qinghe SongXiandang Zhang
Aug 6, 2021·Comprehensive Reviews in Food Science and Food Safety·Wangyan QinGenyi Zhang

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