Medicinal Potentialities of Plant Defensins: A Review with Applied Perspectives

Medicines
Nida IshaqHafiz M N Iqbal

Abstract

Plant-based secondary metabolites with medicinal potentialities such as defensins are small, cysteine-rich peptides that represent an imperative aspect of the inherent defense system. Plant defensins possess broad-spectrum biological activities, e.g., bactericidal and insecticidal actions, as well as antifungal, antiviral, and anticancer activities. The unique structural and functional attributes provide a nonspecific and versatile means of combating a variety of microbial pathogens, i.e., fungi, bacteria, protozoa, and enveloped viruses. Some defensins in plants involved in other functions include the development of metal tolerance and the role in sexual reproduction, while most of the defensins make up the innate immune system of the plants. Defensins are structurally and functionally linked and have been characterized in various eukaryotic microorganisms, mammals, plants, gulls, teleost species of fish, mollusks, insect pests, arachnidan, and crustaceans. This defense mechanism has been improved biotechnologically as it helps to protect plants from fungal attacks in genetically modified organisms (GMO). Herein, we review plant defensins as secondary metabolites with medicinal potentialities. The first half of the review elab...Continue Reading

References

Apr 1, 1997·FEMS Microbiology Letters·Y Zhang, K Lewis
May 20, 1999·Biopolymers·F García-OlmedoP Rodríguez-Palenzuéla
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·K ThevissenW F Broekaert
Jun 27, 2001·Applied and Environmental Microbiology·C P Selitrennikoff
Jul 10, 2002·The Journal of Peptide Research : Official Journal of the American Peptide Society·X Y Ye, T B Ng
Jul 26, 2002·Plant Molecular Biology·Hyeong Cheol ParkMoo Je Cho
Nov 26, 2002·Planta·Bart P H J ThommaKarin Thevissen
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nannette Y Yount, Michael R Yeaman
Sep 24, 2004·Biochemical and Biophysical Research Communications·Haryadi Sugiarto, Pak-Lam Yu
Jan 11, 2005·Current Protein & Peptide Science·F T Lay, M A Anderson
Feb 17, 2005·Journal of Agricultural and Food Chemistry·Gan-Hong ChenChing-San Chen
May 3, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Patrick H K Ngai, T B Ng
May 18, 2005·The International Journal of Biochemistry & Cell Biology·Jack Ho Wong, Tzi Bun Ng
Aug 3, 2005·Nature Reviews. Cancer·Mark M Fuster, Jeffrey D Esko
Aug 9, 2005·The International Journal of Biochemistry & Cell Biology·Patrícia B Pelegrini, Octávio L Franco
Sep 1, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Brian C Monk, David R K Harding
Sep 1, 2005·Molecular and Cellular Biochemistry·Izabela DobrzyńskaZbigniew Figaszewski
Sep 7, 2005·Cellular and Molecular Life Sciences : CMLS·S ZhuJ Tytgat
Nov 15, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Jack H Wong, T B Ng
Mar 17, 2006·Molecular Immunology·Jun ZouChris Secombes
Apr 11, 2006·Annual Review of Phytopathology·L C van LoonC M J Pieterse
May 12, 2006·Peptides·Jack Ho WongTzi Bun Ng
Jun 24, 2006·The Plant Journal : for Cell and Molecular Biology·Marie MirouzeLaurence Marquès
Jun 24, 2006·Biotechnology Letters·José L Anaya-LópezAlejandra Ochoa-Zarzosa
Jul 11, 2006·The FEBS Journal·Octávio L FrancoCarlos Bloch
Dec 7, 2007·Immunogenetics·Shunyi Zhu
Mar 15, 2008·The Journal of Biological Chemistry·Nicole L van der WeerdenMarilyn A Anderson
May 13, 2008·Biochemical and Biophysical Research Communications·Ekaterina I FinkinaTatiana V Ovchinnikova

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Citations

Jul 31, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Letícia Machado GonçalvesCristina de Andrade Monteiro
Jun 20, 2019·Medicines·Ana M L Seca, Diana C G A Pinto
Jan 23, 2021·Critical Reviews in Food Science and Nutrition·Laila N ShwaikiKieran M Lynch
Aug 29, 2021·Pharmaceuticals·Nour Mammari On Behalf Of The Oemonom
Dec 17, 2021·Scientific Reports·Binish KhaliqAhmed Akrem

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