Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
E Alvarez-SalasP de Gortari

Abstract

Thyrotropin-releasing hormone (TRH) synthesized in hypothalamic paraventricular nucleus directs hypothalamus-pituitary-thyroid (HPT) axis function, regulating thyrotropin release from adenohypophysis and thyroid hormones serum concentration. Pyroglutamyl aminopeptidase II (PPII), a Zn-dependent metallopeptidase located in adenohypophysis and medial-basal-hypothalamus degrades TRH released from the median eminence and participates in HPT axis function by regulating TRH-induced thyrotropin release from adenohypophysis. It is unknown whether dietary Zn deficiency down-regulates PPII. Our aim was to compare adenohypohyseal and medial-basal-hypothalamic PPII activity and expression of adult rats fed a Zn-deficient diet (2ppm) throughout their lifespan (DD), prenatally (DC) or after weaning (CD) vs. that of animals fed a control diet (20ppm:CC). Female rats consumed a Zn-deficient or control diet from two weeks before gestation and up to the end of lactation. We analyzed adenohypophyseal and medial-basal-hypothalamic PPII activity of dams and male offspring when adults; its relation to median eminence TRH, serum thyrotropin, leptin and thyroid hormones concentration. Offspring ate the same diet as their dams (CC, DD) or were switched...Continue Reading

References

Apr 24, 1992·Brain Research. Developmental Brain Research·M A VargasP Joseph-Bravo
Jun 8, 1973·Biochemical and Biophysical Research Communications·F LaBellaG Queen
Nov 1, 1970·Endocrinology·J B MartinS Reichlin
Dec 1, 1984·The American Journal of Clinical Nutrition·M S GolubA G Hendrickx
Nov 1, 1983·Neuroendocrinology·I S LoginR M MacLeod
Jul 1, 1984·Experimental Neurology·E J Kasarskis
Mar 21, 1994·Brain Research·A TakedaS Okada
Jan 1, 1993·Physiological Reviews·B L Vallee, K H Falchuk
Aug 13, 1998·The American Journal of Clinical Nutrition·L E CaulfieldM Merialdi
Apr 14, 1999·Biological Trace Element Research·I BucciF Monaco
Oct 12, 1999·Molecular Endocrinology·C Baratti-ElbazE Milgrom
May 10, 2000·The Journal of Nutrition·N F Shay, H F Mangian
Jul 6, 2002·The Journal of Endocrinology·T M Ortiga-CarvalhoC C Pazos-Moura
Apr 22, 2003·Journal of Neuroscience Research·Atsushi TakedaNaoto Oku
Jun 6, 2003·Journal of Neurochemistry·Atsushi TakedaNaoto Oku
Jan 31, 2004·Thyroid : Official Journal of the American Thyroid Association·Masanobu YamadaMasatomo Mori
Jun 3, 2004·The Journal of Nutrition·Winyoo ChowanadisaiBo Lönnerdal

❮ Previous
Next ❯

Citations

Jun 7, 2016·Biological Trace Element Research·Abdulkerim Kasim BaltaciRasim Mogulkoc
Dec 21, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Helge Müller-Fielitz, Markus Schwaninger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.