Mediterranean diet and risk for Alzheimer's disease.

Annals of Neurology
Nikolaos ScarmeasJose A Luchsinger

Abstract

Previous research in Alzheimer's disease (AD) has focused on individual dietary components. There is converging evidence that composite dietary patterns such as the Mediterranean diet (MeDi) is related to lower risk for cardiovascular disease, several forms of cancer, and overall mortality. We sought to investigate the association between MeDi and risk for AD. A total of 2,258 community-based nondemented individuals in New York were prospectively evaluated every 1.5 years. Adherence to the MeDi (zero- to nine-point scale with higher scores indicating higher adherence) was the main predictor in models that were adjusted for cohort, age, sex, ethnicity, education, apolipoprotein E genotype, caloric intake, smoking, medical comorbidity index, and body mass index. There were 262 incident AD cases during the course of 4 (+/-3.0; range, 0.2-13.9) years of follow-up. Higher adherence to the MeDi was associated with lower risk for AD (hazard ratio, 0.91; 95% confidence interval, 0.83-0.98; p=0.015). Compared with subjects in the lowest MeDi tertile, subjects in the middle MeDi tertile had a hazard ratio of 0.85 (95% confidence interval, 0.63-1.16) and those at the highest tertile had a hazard ratio of 0.60 (95% confidence interval, 0.4...Continue Reading

References

Jul 1, 1986·American Journal of Epidemiology·W Willett, M J Stampfer
Jul 1, 1985·American Journal of Epidemiology·W C WillettF E Speizer
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Sep 17, 1994·Lancet·J L Witztum
Nov 12, 1994·Lancet·I RajmanR Cramb
Dec 2, 1995·BMJ : British Medical Journal·A TrichopoulouD Trichopoulos
Jan 1, 1997·American Journal of Epidemiology·S KalmijnD Kromhout
Jan 1, 1997·The American Journal of Clinical Nutrition·A La RueP J Garry
Dec 10, 1997·Annals of Neurology·S KalmijnM M Breteler
Mar 25, 2000·The American Journal of Clinical Nutrition·C LasherasA M Patterson
Aug 26, 2000·European Journal of Epidemiology·D CommengesJ F Dartigues
Dec 22, 2000·The American Journal of Clinical Nutrition·P F Jacques, K L Tucker
Jun 20, 2001·Annals of Internal Medicine·K J JoshipuraW C Willett
Feb 7, 2002·Lancet·Annemieke RuitenbergMonique M B Breteler
Jun 28, 2002·JAMA : the Journal of the American Medical Association·Marianne J EngelhartMonique M B Breteler
Jun 22, 2002·JAMA : the Journal of the American Medical Association·Martha Clare MorrisPaul A Scherr
Jul 16, 2002·Archives of Neurology·Martha Clare MorrisRobert S Wilson
Aug 8, 2002·Archives of Neurology·Jose A LuchsingerRichard Mayeux
Oct 26, 2002·BMJ : British Medical Journal·Pascale Barberger-GateauSerge Renaud
Nov 13, 2002·Neurology·Thomas TruelsenUNKNOWN Copenhagen City Heart Study
Dec 25, 2002·Neurology·M J EngelhartM M B Breteler
Jan 24, 2003·Journal of Neural Transmission·V SolfrizziA Capurso
Feb 13, 2003·Archives of Neurology·Martha Clare MorrisRobert S Wilson
Feb 13, 2003·Archives of Neurology·Jose A LuchsingerRichard Mayeux
Mar 15, 2003·JAMA : the Journal of the American Medical Association·Kenneth J MukamalDavid S Siscovick
Jun 27, 2003·The New England Journal of Medicine·Antonia TrichopoulouDimitrios Trichopoulos
Jul 23, 2003·Journal of Hypertension·Demosthenes B PanagiotakosPavlos K Toutouzas
Jul 23, 2003·Archives of Neurology·Martha Clare MorrisJulie Schneider

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Citations

Sep 10, 2008·Archives of Internal Medicine·Nikolaos ScarmeasYaakov Stern
Oct 13, 2006·Archives of Neurology·Nikolaos ScarmeasJose A Luchsinger
Feb 11, 2009·Archives of Neurology·Nikolaos ScarmeasJose A Luchsinger
Apr 14, 2010·Archives of Neurology·Yian GuNikolaos Scarmeas
Feb 15, 2012·Archives of Neurology·Hannah GardenerClinton B Wright
Aug 13, 2009·JAMA : the Journal of the American Medical Association·Nikolaos ScarmeasYaakov Stern
Aug 13, 2009·JAMA : the Journal of the American Medical Association·Catherine FéartPascale Barberger-Gateau
Aug 13, 2009·JAMA : the Journal of the American Medical Association·David S Knopman
Apr 26, 2007·Der Nervenarzt·C HausteinerJ Grassmann
Jan 27, 2012·Zeitschrift für Gerontologie und Geriatrie·M C Polidori, L Pientka
Jul 20, 2007·European Archives of Psychiatry and Clinical Neuroscience·H Georg KuhnPaul J Lucassen
Jun 9, 2007·Journal of Neural Transmission·M WeihJ Kornhuber
Sep 4, 2007·Current Neurology and Neuroscience Reports·José A LuchsingerNikolaos Scarmeas
Aug 22, 2013·Current Neurology and Neuroscience Reports·James M NoblePanos N Papapanou
Jul 20, 2011·The British Journal of Nutrition·Martin Loef, Harald Walach
Aug 9, 2013·The British Journal of Nutrition·Stéphane V SizonenkoJohn W Sijben
Dec 12, 2012·The Proceedings of the Nutrition Society·Catherine FéartPascale Barberger-Gateau
May 24, 2008·International Psychogeriatrics·Constantine G LyketsosPeter P Zandi
Jul 12, 2011·Public Health Nutrition·Alejandra A Benítez-ArciniegaHelmut Schröder
Sep 20, 2011·Public Health Nutrition·Reiko HirasawaHirohito Sone
Feb 10, 2011·Nature Reviews. Neurology·Christiane ReitzRichard Mayeux
Oct 4, 2012·Translational Psychiatry·S GardenerUNKNOWN AIBL Research Group
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·A V WitteA Flöel
May 15, 2013·Journal of Nutrition in Gerontology and Geriatrics·Michael L AloscoJohn Gunstad
Mar 22, 2013·Journal of Medicinal Food·Konstantinos KatsiardanisEleni T Petridou
Sep 10, 2008·Epidemiologic Reviews·Nicola ColeyAlain Grand
May 28, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·B C M StephanM Siervo
Dec 22, 2010·International Journal of Epidemiology·Miguel Ángel Martínez-GonzálezUNKNOWN PREDIMED Study Investigators
Oct 17, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Catherine FéartPascale Barberger-Gateau
Dec 20, 2007·Alzheimer Disease and Associated Disorders·Richard Mayeux
Mar 5, 2008·Alzheimer Disease and Associated Disorders·Lissy JarvikAlan B Zonderman
Aug 16, 2008·Alzheimer Disease and Associated Disorders·Christianna PurnellHugh C Hendrie
May 25, 2011·Alzheimer Disease and Associated Disorders·Yian GuNikolaos Scarmeas
Jun 7, 2007·Current Opinion in Psychiatry·Chengxuan QiuLaura Fratiglioni
Aug 26, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P J Kamphuis, R J Wurtman
Jan 25, 2008·Acta Pharmacologica Sinica·Hong-fang Ji, Hong-yu Zhang
Nov 15, 2011·BMJ : British Medical Journal·Dilip V Jeste
Nov 29, 2007·Neuroepidemiology·Nikolaos Scarmeas, Elan D Louis
Feb 3, 2009·Dementia and Geriatric Cognitive Disorders·Tasnime N AkbaralyEric J Brunner
Nov 6, 2009·Dementia and Geriatric Cognitive Disorders·Claudine BerrKaren Ritchie

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