PMID: 16522903Mar 9, 2006Paper

Mediterranean-inspired diet lowers the ratio of serum phospholipid n-6 to n-3 fatty acids, the number of leukocytes and platelets, and vascular endothelial growth factor in healthy subjects

The American Journal of Clinical Nutrition
Anneli AmbringPeter Friberg

Abstract

Reduced cardiovascular mortality and morbidity have been shown in persons adhering to Mediterranean-inspired diets (MIDs). Although the underlying mechanisms of this association are poorly understood, the importance of increasing dietary amounts of polyunsaturated fatty acids of the n-3 series has been emphasized. We investigated whether a MID provided to healthy subjects would affect 1) the inflammatory process and endothelial indexes such as vasoregulation and vascular endothelial growth factor (VEGF) and 2) serum phospholipid fatty acid composition. A total of 22 subjects (10 women) received a MID or an ordinary Swedish diet (OSD) for 4 wk in a crossover fashion. Concentrations of lipids and fatty acids, high-sensitivity C-reactive protein, and interleukin 6, both before and after lipopolysaccharide stimulation; the number of leukocytes and platelets; and VEGF and monocyte chemoattractant protein 1 were analyzed. The plasma ratio of n-6 to n-3 fatty acids was substantially lower after the MID than after the OSD (x +/- SEM: 4.72 +/- 0.19 and 2.60 +/- 0.17, respectively; P < 0.0001). Neither C-reactive protein nor interleukin 6 concentrations changed significantly after the MID compared with the OSD. The total number of leukoc...Continue Reading

References

Jan 1, 1989·Journal of Internal Medicine. Supplement·S Renaud, M de Lorgeril
Oct 1, 1988·European Journal of Immunology·M HelleL A Aarden
Jan 1, 1996·Annual Review of Nutrition·P D Reaven, J L Witztum
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MöhleS Rafii
Oct 10, 1998·European Journal of Clinical Investigation·I SeljeflotI Hjermann
Oct 26, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C PompéiaR Curi
Apr 3, 2001·Circulation·P Kris-EthertonUNKNOWN Nutrition Committee Population Science Committee and Clinical Science Committee of the American Heart Association
Dec 20, 2002·Nature·Peter Libby
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Maria Annunziata CarluccioRaffaele De Caterina
Jun 27, 2003·The New England Journal of Medicine·Antonia TrichopoulouDimitrios Trichopoulos
Jul 24, 2003·JAMA : the Journal of the American Medical Association·David J A JenkinsPhilip W Connelly
Sep 24, 2004·JAMA : the Journal of the American Medical Association·Katherine EspositoDario Giugliano
Feb 9, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marina KorotkovaBirgitta Strandvik

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Citations

Oct 11, 2007·European Journal of Epidemiology·A TrichopoulouD Trichopoulos
Mar 27, 2010·Journal of the American College of Nutrition·Barry Sears
Oct 22, 2011·Cancer Metastasis Reviews·Isabelle M BerquinYong Q Chen
Mar 5, 2016·British Journal of Clinical Pharmacology·Marialaura BonaccioUNKNOWN MOLI-SANI Study Investigators
Oct 4, 2016·Public Health Nutrition·Ulla HauteroKirsi Laitinen
Sep 2, 2016·Environmental Health : a Global Access Science Source·Kyoung-Nam KimYun-Chul Hong
Jun 13, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jirayu TanprasertsukElizabeth J Johnson
Sep 5, 2019·Nutrients·Beatriz Martínez-PovedaAna R Quesada
Jul 29, 2020·Nutrients·Nirajan ShresthaDeanne H Hryciw
Apr 9, 2009·International Journal of Food Sciences and Nutrition·Demosthenes PanagiotakosChristodoulos Stefanadis
Oct 24, 2012·Cancer Metastasis Reviews·Jing X Kang, Angela Liu
Jan 23, 2017·International Journal of Public Health·Marialaura BonaccioUNKNOWN Moli-sani Study Investigators
Jun 21, 2018·Nutrients·Ivan V Maly, Wilma A Hofmann
Dec 14, 2018·International Journal of Molecular Sciences·Rosa CasasEmilio Sacanella
Sep 22, 2009·Arquivos brasileiros de endocrinologia e metabologia·Jussara C de AlmeidaMirela J de Azevedo
Jan 28, 2014·Journal of Medicinal Food·Hyungjae Lee, Woo Jung Park
Jan 18, 2018·Journal of Human Kinetics·Dominika MaciejewskaEwa Stachowska
Mar 12, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·John Michael S SanchezRobert S Fujinami
Jun 6, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Laura SpencerAshley Dennison
Sep 29, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Birgitta Strandvik

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