Medium-Chain Acylcarnitines Are Associated With Cardioembolic Stroke and Stroke Recurrence

Arteriosclerosis, Thrombosis, and Vascular Biology
Woo-Keun SeoKyungmi Oh

Abstract

Objective- Stroke is a heterogeneous disease with diverse causes, which affect the risk of recurrence. This study aimed to identify novel biomarkers that are clinically relevant to the diagnosis of cardioembolic stroke (CE) and the prediction of stroke recurrence using metabolomics. Approach and Results- We obtained blood samples and clinical data from a consecutively registered, hospital-based acute stroke registry and from healthy controls. Mass-spectrometry-based profiling was performed, and several metabolomic signatures were selected for the discrimination of CE and stroke recurrence, coupled with multivariate statistical analysis. Finally, 190 acute ischemic stroke participants (43 CE patients and 147 non-CE patients) and 30 control participants were included. We obtained 29 metabolomics signatures, and of these, 2 medium-chain acylcarnitines (decanoylcarnitine and octanoylcarnitine) were selected as independent discriminants for CE (odds ratio, 2.839; 95% CI, 1.241-6.493 for decanoylcarnitine; odds ratio, 2.839; 95% CI, 1.241-6.493 for octanoylcarnitine). Elevated medium-chain acylcarnitines were also associated with a higher risk of stroke recurrence (hazard ratio, 3.767; 95% CI, 1.276-11.117 for decanoylcarnitine; haza...Continue Reading

References

Jul 10, 2003·Lancet Neurology·José M Ferro
Oct 22, 2005·Annals of Neurology·Hakan AyWalter J Koroshetz
Jun 1, 1962·The Journal of Clinical Investigation·W E Connor
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Apr 13, 2010·Cardiovascular Engineering·Laurence Pilgeram
Apr 9, 2011·Stroke; a Journal of Cerebral Circulation·Jee Youn JungGeum-Sook Hwang
Aug 2, 2011·Current Cardiology Reviews·Teresa García-BerrocosoJoan Montaner
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Oct 28, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Woo-Keun SeoHong Seok Seo
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Gary J PattiGary Siuzdak
Jul 19, 2012·Clinical Pharmacokinetics·Stephanie E Reuter, Allan M Evans
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Dec 7, 2013·Journal of the American Heart Association·Sahir KalimEugene P Rhee
Feb 18, 2014·Current Cardiology Reviews·Victor LlombartJoan Montaner
Mar 22, 2014·Lancet Neurology·Robert G HartUNKNOWN Cryptogenic Stroke/ESUS International Working Group
May 8, 2014·Stroke; a Journal of Cerebral Circulation·Jeong-Yoon ChoiKyungmi Oh
Dec 5, 2014·Neurology·Mariona JovéFrancisco Purroy
Feb 26, 2015·Diabetes·Sandeep DhindsaParesh Dandona
Mar 15, 2015·Stroke; a Journal of Cerebral Circulation·Víctor LlombartJoan Montaner
Nov 26, 2015·Annals of Neurology·Jeong-Yoon ChoiWoo-Keun Seo
Apr 22, 2016·The American Journal of Clinical Nutrition·Marta Guasch-FerréJordi Salas-Salvadó
Apr 30, 2016·Circulation Research·Elizabeth MurphyUNKNOWN American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Function
Jan 24, 2017·Neuroscience Letters·Dian WangMinchao Lai

❮ Previous
Next ❯

Citations

Nov 23, 2019·Metabolomics : Official Journal of the Metabolomic Society·Chaofu KeYonghong Zhang
Nov 6, 2018·Frontiers in Endocrinology·Tristan StrujaPhilipp Schuetz
Jan 6, 2021·Journal of the American Heart Association·Lars LindJohan Ärnlöv
Jan 24, 2021·Medicina clínica·Xiaoyan LiZhongxin Xu
Jul 3, 2021·Reviews in the Neurosciences·Maria S ChumachenkoSergei V Fedorovich

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Gino GialdiniUbaldo Bonuccelli
Iyō denshi to seitai kōgaku. Japanese journal of medical electronics and biological engineering
A Miyake, S Kaihara
© 2022 Meta ULC. All rights reserved