Medium-Chain Fatty Acids Released from Polymeric Electrospun Patches Inhibit Candida albicans Growth and Reduce the Biofilm Viability.

ACS Biomaterials Science & Engineering
Katharina H ClitherowCraig Murdoch

Abstract

Oral candidiasis is a very common oral condition among susceptible individuals, with the main causative organism being the fungus Candida albicans. Current drug delivery systems to the oral mucosa are often ineffective because of short drug/tissue contact times as well as increased prevalence of drug-resistant Candida strains. We evaluated the potency of saturated fatty acids as antifungal agents and investigated their delivery by novel electrospun mucoadhesive oral patches using agar disk diffusion and biofilm assays. Octanoic (C8) and nonanoic (C9) acids were the most effective at inhibiting C. albicans growth on disk diffusion assays, both in solution or when released from polycaprolactone (PCL) or polyvinylpyrrolidone/RS100 (PVP/RS100) electrospun patches. In contrast, dodecanoic acid (C12) displayed the most potent antifungal activity against pre-existing C. albicans biofilms in solution or when released by PCL or PVP/RS100 patches. Both free and patch-released saturated fatty acids displayed a significant toxicity to wild-type and azole-resistant strains of C. albicans. These data not only provide evidence that certain saturated fatty acids have the potential to be used as antifungal agents but also demonstrate that this ...Continue Reading

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Citations

Jun 6, 2020·Pharmaceutics·Jake G EdmansHelen E Colley
Jul 3, 2021·Journal of the American Chemical Society·Felix PultarErick M Carreira

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Methods Mentioned

BETA
scanning electron microscopy
nuclear magnetic resonance
fluorescence microscopy
infrared spectroscopy

Software Mentioned

GraphPad Prism
TopSpin
GraphPad
Fiji imaging
AxioVision

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