Medium-Chain Triglycerides in Combination with Leucine and Vitamin D Benefit Cognition in Frail Elderly Adults: A Randomized Controlled Trial

Journal of Nutritional Science and Vitaminology
Sakiko AbeMotohisa Suzuki

Abstract

The combined supplementation of medium-chain triglycerides (MCTs), L-leucine-rich amino acids, and cholecalciferol (vitamin D3) increase muscle strength and function in frail elderly individuals. However, their effects on cognition are unknown. We enrolled 38 elderly nursing home residents (mean age±SD, 86.6±4.8 y) in a 3-mo randomized, controlled, parallel group trial. The participants were randomly allocated to 3 groups: the first group received a L-leucine (1.2 g)- and cholecalciferol (20 μg)-enriched supplement with 6 g of MCT (LD+MCT); the second group received the same supplement with 6 g of long-chain triglycerides (LD+LCT); and the third group did not receive any supplements (control). Cognition was assessed at baseline and after the 3-mo intervention. The difference in changes among the groups was assessed with ANCOVA, adjusting for age and the baseline value as covariates. After 3 mo, the Mini-Mental State Examination (MMSE) score in the LD+MCT group increased by 10.6% (from 16.6 to 18.4 points, p<0.05). After 3 mo, the Nishimura geriatric rating scale for mental status (NM scale) score in the LD+MCT group increased by 30.6% (from 24.6 to 32.2 points, p<0.001), whereas that in the LD+LCT and control groups decreased b...Continue Reading

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Citations

Jul 25, 2019·The American Journal of Clinical Nutrition·Sakiko AbeMotohisa Suzuki
Jul 19, 2020·Current Nutrition Reports·Zachary BartochowskiGeorge T Grossberg
Jul 5, 2019·CNS & Neurological Disorders Drug Targets·Javier Caballero-VillarrasoIsaac Túnez
Apr 16, 2020·Alzheimer's Research & Therapy·Matthieu LilamandClaire Paquet
Apr 4, 2021·Brain Sciences·Giulia BivonaMarcello Ciaccio

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