Medium optimization and potential hepatoprotective effect of mycelial polysaccharides from Pholiota dinghuensis Bi against carbon tetrachloride-induced acute liver injury in mice

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Dan GanXiaoxiong Zeng

Abstract

Response surface methodology was employed to optimize the medium compositions for the production of mycelial polysaccharide from Pholiota dinghuensis Bi (PDP). As a result, the optimal medium for crude PDP production was determined as follows (g/L): glucose 36.0, corn flour 11.8, peptone 3.0, yeast extract 5.4, KH(2)PO(4) 1.0, and MgSO(4) 1.5. In a verification experiment, a yield of 756 ± 38 mg/L crude PDP was obtained. Furthermore, biochemical assay and histopathological analysis showed that crude PDP exerted significant hepatoprotective effect in a dose-dependent manner against carbon tetrachloride (CCl(4))-induced acute liver injury. Crude PDP prevented the increase of activities of serum alanine aminotransferase and aspartate aminotransferase, reduced the formation of malondialdehyde and enhanced the activities of superoxide dismutase and glutathione peroxidase in CCl(4)-induced hepatotoxicity in mice.

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Citations

May 25, 2013·Journal of Clinical Biochemistry and Nutrition·Jishu QuanXuezhe Yin
Feb 11, 2016·International Journal of Pharmaceutics·Yingshu FengXiming Xu
Oct 16, 2014·International Journal of Biological Macromolecules·Jun LiuChang-Hai Jin
Jun 5, 2016·International Journal of Biological Macromolecules·Chen ZhangLe Jia
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andréia Assunço SoaresRosane Marina Peralta
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Xiao MengHua-Bin Li

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