Medroxyprogesterone acetate used in ovarian stimulation is associated with reduced mature oocyte retrieval and blastocyst development: a matched cohort study of 825 freeze-all IVF cycles.

Journal of Assisted Reproduction and Genetics
Kemal OzgurKevin Coetzee

Abstract

To compare the effectivity of flexible-start medroxyprogesterone acetate (MPA) co-treatment ovarian stimulations (OS) with flexible-start gonadotropin-releasing hormone antagonist (GnRH-ant) co-treatment OS, in blastocyst freeze-all IVF cycles. This matched cohort study was performed at a single IVF center. Study cycles were extracted from freeze-all IVF cycles performed between February 2015 and June 2018 with cycles grouped according to the co-treatment protocol (MPA and GnRH-ant groups) used. MPA cycles were matched 1:1 using antral follicle count, female age, infertility duration, and female body mass index, with GnRH-ant cycles, resulting in 825 matched cycles. MPA or CET co-treatment was started when leading follicles reached 11-12 mm. Duration of OS was significantly longer, and total FSH dose was significantly higher in the MPA group. Numbers of mature oocytes retrieved were similar; however, the mature oocyte retrieval rate (83.8 vs. 97.1%; p < 0.001), number of blastocysts, blastocyst rate (36.4 vs. 41.4%; p < 0.001) and > 2 viable blastocyst rate were all significantly lower in the MPA group. The live birth (LB) per transfer rates (51.6 vs. 55.7%; p = 0.155) were similar; however, the LB rate per treatment was signif...Continue Reading

References

Oct 14, 2008·European Journal of Endocrinology·Catherine Hayden
Apr 7, 2010·Case Reports in Medicine·Teraporn VutyavanichJason Ellis
Apr 20, 2011·Human Reproduction·UNKNOWN Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology
Jun 11, 2011·Current Pharmaceutical Biotechnology·H M FatemiP Devroey
Aug 11, 2011·Human Reproduction·Paul DevroeyChristophe Blockeel
Nov 28, 2014·Journal of Assisted Reproduction and Genetics·Matheus Roque
Dec 25, 2015·Journal of Assisted Reproduction and Genetics·Kemal OzgurKevin Coetzee
Aug 17, 2016·Reproductive Biomedicine Online·Stella D'ArpeCarlo Bastianelli
Feb 9, 2017·Reproductive Biomedicine Online·Michael M Alper, Bart C Fauser
Sep 6, 2017·Reproductive Biology and Endocrinology : RB&E·Qiuju ChenYanping Kuang
Feb 23, 2019·Journal of Assisted Reproduction and Genetics·Kemal OzgurKevin Coetzee
May 30, 2019·Reproductive Biomedicine Online·Antonio La Marca, Martina Capuzzo

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Citations

Apr 25, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Kemal OzgurKevin Coetzee

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