PMID: 1111937Mar 1, 1975Paper

Medullary carcinoma of the thyroid gland

Cancer
G C ChongL B Woolner

Abstract

One hundred thirty-nine surgically treated patients with medullary carcinoma of the thyroid gland (MTC) were seen in our institution between January, 1926 and December, 1973. The incidence of this tumor among all thyroid cancers was 8%. Twenty-nine patients had the familial form of MTC; they were subclassified, on the basis of the phenotype, into a group of 15 patients with Sipple syndrome (or multiple endocrine neoplasia (MEN) Type 2A) and a group of 14 patients with mucosal-neuroma phenotype (or MEN type 2B). Better survivorship was seen in the younger patients, in those with bilateral tumors, in familial MTC, and in patients whose tumor was confined to the thyroid gland at the initial surgery. The incidence of tumor recurrence was 34%. However, in those with adequate surgical treatment, the recurrence was only 23%. The 5- and 10-year survivorships were 80% and 67%, respectively. The best chance of cure lies in early diagnosis through the use of immunoreactive calcitonin measurement in family members at risk, and an aggressive surgical attack on the primary tumor and any cervical metastases.

References

Jun 1, 1973·Annals of Internal Medicine·C E JacksonM A Block
Aug 1, 1968·The Journal of Clinical Endocrinology and Metabolism·G F DonahowerJ B Hazard
Apr 19, 1966·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A G Pearse
Aug 30, 1973·The New England Journal of Medicine·H J WolfeA H Tashjian
May 1, 1973·Cancer·C M SteinfeldL B Woolner
May 1, 1974·Annals of Surgery·W H RemineE G Harrison
Feb 1, 1971·The Surgical Clinics of North America·E L Kaplan, G W Peskin
Nov 1, 1971·The New England Journal of Medicine·K E MelvinA H Tashjian
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·K E Melvin, A H Tashjian
Oct 22, 1970·The New England Journal of Medicine·A H TashijanC S Hill
Apr 1, 1968·Archives of Surgery·M A BlockR C Horn
Mar 1, 1966·Journal of Clinical Pathology·E D WilliamsI Doniach
Mar 1, 1966·Journal of Clinical Pathology·E D Williams
Sep 1, 1967·Annals of Surgery·M A BlockB E Brush
Jan 1, 1959·The Journal of Clinical Endocrinology and Metabolism·J B HAZARDG CRILE

❮ Previous
Next ❯

Citations

Jan 1, 1979·Acta Radiologica: Oncology, Radiation, Physics, Biology·B Rasmusson, H S Hansen
Sep 1, 1979·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B W PearsonS G Norman
Jan 1, 1986·Journal of Cancer Research and Clinical Oncology·W SchurrR Ziegler
Jul 1, 1982·Klinische Wochenschrift·K H PflügerK Havemann
Oct 1, 1995·The Australian and New Zealand Journal of Surgery·B T TehN Hayward
Jul 1, 1995·Journal of Surgical Oncology·L A MarzanoL Zarrilli
Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·D J MarshB G Robinson
Jun 18, 1998·The American Journal of Surgical Pathology·K KasererB Niederle
Jul 21, 1998·Thyroid : Official Journal of the American Thyroid Association·M E GirelliB Busnardo
Jul 13, 2002·Expert Review of Anticancer Therapy·E BajettaM Del Vecchio
Jan 13, 2005·The American Journal of Surgical Pathology·J Aidan Carney
Sep 16, 2005·The New England Journal of Medicine·Michael A SkinnerSamuel A Wells
Jul 7, 2007·Thyroid : Official Journal of the American Thyroid Association·Simona Grozinsky-GlasbergMordechai Lapidot
May 15, 1990·Cancer·H Galera-DavidsonM Bibbo
Nov 1, 1988·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S J PearlmanH F Biller
Jan 1, 1982·Histopathology·H GaleraI Martin
Dec 1, 1985·World Journal of Surgery·M BäckdahlT Löwhagen
Mar 1, 1982·Acta Pathologica Japonica·K KakudoF Matsuzuka
Jan 1, 1981·Journal of Surgical Oncology·J B Hazard
May 1, 1980·Veterinary Pathology·G G LongH Heath
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·J BetkaJ Skrivan
Jan 1, 1997·Pediatric Surgery International·T Kusafuka, P Puri
Jul 17, 1998·The Journal of Pathology·D G WangK D Buchanan
Sep 25, 1999·Diseases of the Colon and Rectum·S R GrobmyerM F Brennan
Jul 29, 1998·Journal of Internal Medicine·J F MoleyS A Wells
Jun 1, 2000·Cancer Control : Journal of the Moffitt Cancer Center·G W Randolph, D Maniar
Aug 8, 2007·Journal of the Royal Society of Medicine·S GuptaR C G Pollok

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.