PMID: 3768674Sep 10, 1986Paper

Medullary pressor area: site of action of intravenous physostigmine

Brain Research
S PunnenH N Sapru

Abstract

Physostigmine, a choline-esterase inhibitor, is known to elevate endogenous levels of acetylcholine. Intravenously administered physostigmine causes a rise in blood pressure via its action in the central nervous system. Exact site of this action of physostigmine is not known. In this paper, it was demonstrated that microinjections of tetrodotoxin (a fast sodium channel blocker), lidocaine (a local anesthetic) and scopolamine (a cholinergic muscarinic receptor blocker) into the rostral ventrolateral medullary pressor area abolished the pressor action of intravenously administered physostigmine. These results demonstrate that the rostral ventrolateral medulla is the site of action of intravenously administered physostigmine and this action is mediated via cholinergic muscarinic receptors.

References

Nov 1, 1978·Brain Research Bulletin·H N Sapru, A J Krieger
Oct 1, 1979·Journal of the Autonomic Nervous System·K AmendtH Seller
Dec 1, 1974·European Journal of Pharmacology·H E Brezenoff, J Rusin
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·R A Dampney
Sep 1, 1983·Neuropharmacology·T Kubo, Y Misu
Mar 1, 1982·Brain Research Bulletin·H N SapruA J Krieger
Sep 1, 1955·British Journal of Pharmacology and Chemotherapy·V VARAGIC

❮ Previous
Next ❯

Citations

May 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·C A Taira, M A Enero
Mar 31, 2012·Brain Structure & Function·Ruth L StornettaPatrice G Guyenet
Nov 6, 1989·Brain Research·J MurugaianH Sapru
Jan 17, 1989·European Journal of Pharmacology·C A Taira, M A Enero
Sep 1, 1992·Neuropharmacology·Y HaraS Murayama
Dec 1, 1994·Neuropharmacology·V L Peres-Polon, F M Corrêa
Apr 1, 1988·Journal of the Autonomic Nervous System·K Sundaram, H Sapru
Nov 1, 1989·Journal of the Autonomic Nervous System·J J Buccafusco, V Magri
Jul 1, 1990·Brain Research Bulletin·J J Buccafusco, V Magri
Jun 1, 1994·The Journal of Pharmacy and Pharmacology·G R TrimarchiG Costa
Jan 1, 1991·Drug Metabolism and Drug Interactions·V M VaragicS Vujnov
Apr 9, 1998·Clinical and Experimental Hypertension : CHE·T KuboR Fukumori
Feb 21, 2006·Neuropharmacology·Sanja MilutinovićNina Japundzić-Zigon
Jun 22, 2011·Autonomic Neuroscience : Basic & Clinical·Ana C TakakuraJosé V Menani
Dec 9, 2014·The Journal of Surgical Research·Rabea VerhaeghHerbert de Groot
Oct 3, 2001·Physiological Reviews·H E de Wardener

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.