PMID: 1197947Jun 11, 1975Paper

Medullary relay neurons in the carotid-body chemoreceptor pathway of cats

Respiration Physiology
R O Davies, M W Edwards

Abstract

Central terminations of the carotid body chemoreceptor afferents were localized by recording field potentials and unit activity evoked by electrical stimulation of the carotid sinus nerve, and unit activity during chemical stimulation of the chemoreceptors. Areas where evoked responses with short latency could be recorded and which contained neurons that responded to carotid body excitation were located in two regions of the medulla, about the level of the obex: a dorsal region which included the nucleus tractus solitarius and the reticular formation just below this nucleus; and a ventrolateral region which included the nucleus ambiguus and the ventrolateral reticular formation around that nucleus. The evoked field responses in the two regions were similar. In these two regions, the only neurons which increased their firing both to NaCN and a decreased PIO2 had a respiratory, bursting activity which was phase locked with phrenic nerve firing. The authors' findings suggest that there is a direct synaptic input from carotid body chemoreceptor afferents onto medullary respiratory neurons.

References

Nov 1, 1971·Respiration Physiology·A M Black, R W Torrance
Dec 21, 1973·Brain Research·R O Davies, M W Edwards
Oct 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·G K Weiss, K G Kastella
Jan 1, 1966·Experimental Neurology·R S NeslandH D Siedler
Nov 1, 1967·Experimental Neurology·H L Batsel
Jun 1, 1964·The Journal of Comparative Neurology·M K COTTLE
Mar 1, 1965·Experimental Neurology·H L BATSEL

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Citations

Sep 1, 1989·Pflügers Archiv : European journal of physiology·E E LawsonP M Lalley
Sep 16, 1983·European Journal of Pharmacology·M LaubieH Schmitt
Apr 1, 1979·Respiration Physiology·S A WardE S Petersen
Mar 1, 1981·Respiration Physiology·M MaskreyS C Nicol
May 1, 1990·Respiration Physiology·S L Thompson-GormanW Mitzner
Oct 1, 1979·Journal of the Autonomic Nervous System·J Ciriello, F R Calaresu
Jun 1, 1983·Brain Research·A J MillerR Silverstein
Jan 1, 1986·Progress in Neurobiology·S Long, J Duffin
Sep 11, 1987·Neuroscience Letters·S Matsumoto, T Nagamine
Jul 21, 1977·The New England Journal of Medicine·A J BergerJ W Severinghaus
Jan 1, 1988·Annals of the New York Academy of Sciences·G G Haddad, D F Donnelly
Jul 13, 1999·Journal of Neurophysiology·Z LiB G Lindsey

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