Medullary thyroid cancer and pseudocirrhosis: case report and literature review.

Current Oncology
B L HarryJ R Diamond

Abstract

Pseudocirrhosis is a rare form of liver disease that can cause clinical symptoms and radiographic signs of cirrhosis; however, its histologic features suggest a distinct pathologic process. In the setting of cancer, hepatic metastases and systemic chemotherapy are suspected causes of pseudocirrhosis. Here, we present a patient with medullary thyroid carcinoma metastatic to the liver who developed pseudocirrhosis while on maintenance sunitinib after receiving 5-fluorouracil, leucovorin, and oxaliplatin (folfox) in combination with sunitinib. Cirrhotic change in liver morphology was accompanied by diffusely infiltrative carcinomatous disease resembling the primary tumor. We discuss the diagnosis of pseudocirrhosis in this case and review the literature regarding pseudocirrhosis in cancer.

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Citations

Feb 13, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Su Lim LeeHye Sung Won
Jun 9, 2019·Breast Cancer Research and Treatment·Caspian OliaiSara A Hurvitz
Jul 10, 2013·Clinical and Molecular Hepatology·Woo Kyoung JeongJinoo Kim
Jan 27, 2017·Molecular and Clinical Oncology·Kensuke KumamotoKazutomo Togashi
Apr 27, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tomoyoshi AoyagiHiroshi Matsuzaki
Dec 10, 2021·Molecular and Clinical Oncology·Tomohito ShinodaMakoto Yamada

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