PMID: 15967087Jun 22, 2005Paper

Medullary thyroid carcinoma: management of lymph node metastases

Current Treatment Options in Oncology
Frank J Quayle, Jeffrey F Moley

Abstract

Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy of the thyroid C cells. Spread of MTC commonly occurs to cervical and mediastinal lymph nodes. MTC cells do not concentrate radioactive iodine, and are not sensitive to hormonal manipulation. Because of these features, the treatment of metastatic or recurrent MTC is different from the treatment of differentiated thyroid cancer. Surgery is the only effective therapy at present that can result in cure, or reduction in tumor burden, or effective palliation. Systematic surgical removal of at-risk or involved lymph node basins should be done in patients with palpable primary tumors and recurrence. A "berry-picking" approach is discouraged. Although data are limited, standard chemotherapy and radiation therapy have not been effective in the treatment of MTC. Newer targeted drug therapies are being examined in therapeutic clinical trials.

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Citations

Nov 4, 2010·Annals of Surgical Oncology·Emad KandilRalph P Tufano
Apr 12, 2007·World Journal of Surgery·Jeffrey F Moley, Elizabeth A Fialkowski
Dec 19, 2015·Critical Reviews in Clinical Laboratory Sciences·Mehdi HedayatiFarinaz Afsari
Dec 5, 2013·Expert Opinion on Drug Discovery·Michael W Sim, Mark Steven Cohen
Dec 21, 2010·Seminars in Oncology·Susan C Pitt, Jeffrey F Moley
Jun 6, 2007·Hematology/oncology Clinics of North America·Ana O Hoff, Paulo M Hoff
Nov 30, 2006·Journal of Surgical Oncology·Elizabeth A Fialkowski, Jeffrey F Moley
Mar 17, 2018·Clinical Journal of Oncology Nursing·Lynn Jakobs
Dec 4, 2012·Current Opinion in Oncology·Michael J CampbellJessica Gosnell
Apr 2, 2016·Oncotarget·Sandra LassallePaul Hofman
Jun 24, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Anna Margherita MaffioneDomenico Rubello
Jun 22, 2012·Drugs·James E Frampton
Sep 4, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Gillian M KeatingJames E Frampton
Apr 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Marjan Zarif YeganehMehdi Hedayati

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