Medullary thyroid carcinoma

Current Treatment Options in Oncology
J F Moley


Medullary thyroid carcinoma (MTC) is a neuroendocrine malignancy that occurs in hereditary (25%) and sporadic (75%) clinical settings. MTC is present in all patients with the multiple endocrine neoplasia type 2 syndromes. MTCs produce calcitonin, the measurement of which can indicate the presence of tumors in people who are at risk and the effectiveness of therapy in treated patients. Surgical cure is possible in young patients with multiple endocrine neoplasia type 2 who undergo preventative thyroidectomy (approximately 50% of patients who are diagnosed with a palpable thyroid mass) and in some patients with recurrent nodal metastatic disease in the neck. Mortality from MTC is caused by tumor invasion of the trachea, great vessels in the neck, or mediastinum or by the effects of distant metastatic disease. Surgery for cervical recurrence can prevent death from tracheal invasion. The role of radiation therapy is not well defined. There is no effective systemic therapy for MTC. Activating mutations in a tyrosine kinase receptor gene (RET) are present in most MTCs, and experience with tyrosine kinase inhibitors and other agents in clinical trials is critical for the identification of effective systemic treatment.


Feb 1, 1979·The Surgical Clinics of North America·S A WellsR S Gray
Jan 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T D NguyenG Chaplain
Jan 1, 1990·Acta Oncologica·P GröhnM Jakobsson
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·H ScherüblR Ziegler
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M F SaadN A Samaan
Jul 1, 1980·Clinics in Endocrinology and Metabolism·G W SizemoreJ A Carney
Dec 1, 1995·Surgery·D S O'RiordainJ A van Heerden
Oct 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F OrlandiA Angeli
Sep 29, 1994·The New England Journal of Medicine·C J LipsM J Berends
Jul 1, 1993·Human Molecular Genetics·H Donis-KellerS A Wells
Mar 1, 1996·Endocrinology and Metabolism Clinics of North America·J D Brierley, R W Tsang
Jun 1, 1997·Annals of Surgery·J F MoleyM K DeBenedetti
Mar 27, 1998·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S A Wells, M A Skinner
Sep 24, 1999·Current Problems in Surgery·J F MoleyJ E Phay
May 1, 2002·Annals of Surgery·Mark S CohenJeffrey F Moley
Aug 23, 2002·The British Journal of Surgery·H Dralle
Nov 20, 2002·Cancer Immunology, Immunotherapy : CII·Matthias SchottJochen Seissler

❮ Previous
Next ❯


May 29, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Rafał CzepczyńskiAlberto Signore
Jul 23, 2013·Indian Journal of Endocrinology and Metabolism·Rafael Loch BatistaMalebranche Berardo C Cunha-Neto
Feb 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Marinella Messina, Bruce G Robinson
Mar 26, 2008·Pediatric Hematology and Oncology·Soumen Khatua, Laura L Bilodeau
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
Nov 28, 2013·Annual Review of Medicine·Tobias Carling, Robert Udelsman
Mar 6, 2017·Oncology Reports·Zongping WangYouben Fan
Mar 16, 2005·The American Journal of Surgical Pathology·Veli-Matti WaseniusHeikki Joensuu

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.