Medulloblastoma: A common pediatric tumor: Prognostic factors and predictors of outcome

Asian Journal of Neurosurgery
Lachi Pavan KumarK V J R Naidu

Abstract

Medulloblastoma is a common malignancy in the pediatric population, accounting for 25% of all childhood brain tumors and relatively uncommon in adults. This review was to investigate treatment outcome and prognostic factors after treatment of medulloblastoma. A total of 53 patients with histological confirmed medulloblastoma cases treated at our institute between 2006 and 2012 were included in the study. Demographic variables, clinical variables, radiological findings and treatment details with respect to age, sex, signs and symptoms, location of tumor, extent of surgical resection, histopathology type, radiotherapy dose, follow-up period and outcomes were recorded. Survival was analyzed by using these parameters. Thirty-one (58.5%) patients were pediatric (<14 years), and 22 (41.5%) patients were adults (≥14 years). Duration of symptoms were <3 months in 19 (36%) and more than 3 months in 34 (64%) patients. Tumor resection was performed in all patients with gross total resection in 8 (15%) patients, near total resection in 34 (64%) patients and subtotal resection in 11 (21%) patients. All patients underwent postoperative craniospinal irradiation (CSI) delivering a median craniospinal dose of 36 Gy with additional boosts to the...Continue Reading

Citations

Jan 18, 2017·Journal of Radiation Research·Sanziana R I SchiopuFlorian Sterzing
Dec 6, 2017·Journal of Pediatric Neurosciences·Supriya Gujjar SureshSanjay Chandrasekar
Sep 1, 2019·Scientific Reports·Maha YehiaShahenda El-Naggar
Jun 9, 2020·Frontiers in Genetics·Dustin B Miller, Stephen R Piccolo
May 26, 2018·Journal of Neuro-oncology·Eric M ThompsonVijay Ramaswamy
Nov 28, 2020·Current Treatment Options in Oncology·Hussein HammoudSanaa Nabha
May 6, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Wai Cheong SoonRyan Koshy Mathew

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