Medulloblastoma development: tumor biology informs treatment decisions

CNS Oncology
Vidya GopalakrishnanSoumen Khatua

Abstract

Medulloblastoma is the most common malignant pediatric brain tumor. Current treatments including surgery, craniospinal radiation and high-dose chemotherapy have led to improvement in survival. However, the risk for recurrence as well as significant long-term neurocognitive and endocrine sequelae associated with current treatment modalities underscore the urgent need for novel tumor-specific, normal brain-sparing therapies. It has also provided the impetus for research focused on providing a better understanding of medulloblastoma biology. The expectation is that such studies will lead to the identification of new therapeutic targets and eventually to an increase in personalized treatment approaches.

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Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT00822458
NCT01878617
NCT01601184
NCT01125800
NCT01576666
NCT01231919
NCT01141244
NCT01431534
NCT01431547
NCT01670175

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