Meeting Calorie and Protein Needs in the Critical Care Unit: A Prospective Observational Pilot Study

Nutrition and Metabolic Insights
Shinobu YamamotoMaureen B Huhmann

Abstract

Inadequate calorie and protein intake during critical illness is associated with poor clinical outcomes. Unfortunately, most critically ill patients do not consume adequate levels of these nutrients. An enteral formula with appropriate macronutrient composition may assist patients in meeting nutritional goals. This study was a single center, prospective, observational study of 29 adults in the medical intensive care unit who required enteral nutrition for at least 3 days. Subjects received a calorically dense, enzymatically hydrolyzed 100% whey peptide-based enteral formula for up to 5 days to assess the ability to achieve 50% of caloric goals within the first 3 days (primary outcome), the daily percentage of protein goals attained and gastrointestinal tolerance (secondary outcomes). A total of 29 subjects consented and began the study. Four subjects dropped out before first day and 25 subjects were included in analyses. Subjects were aged 55.5 ± 16.9 years with mean body mass index (BMI) of 27.9 ± 7.5 kg/m2. Most (92%) subjects were on a mechanical ventilator and experienced organ failure. At least 50% of caloric and protein goals were achieved in 78.9% and 73.7% of the subjects, respectively, during the first 3 days. Overall,...Continue Reading

References

Sep 1, 1980·Drugs·D C Ruppin, W R Middleton
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y BoirieB Beaufrère
Aug 14, 1999·Critical Care Medicine·S A McClaveH L Snider
Sep 13, 2003·Nestlé Nutrition Workshop Series. Clinical & Performance Programme·Frederick A Moore, Norman W Weisbrodt
Jan 17, 2013·JAMA : the Journal of the American Medical Association·Jean ReignierUNKNOWN Clinical Research in Intensive Care and Sepsis (CRICS) Group
Jun 27, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Sue-Joan Chang, Hsiu-Hua Huang
Mar 19, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Usha GungabissoonDaren K Heyland
Apr 30, 2014·The Health Care Manager·Alex HunterAlberto Coustasse
Aug 5, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Daren K HeylandAndrew G Day
Apr 23, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Michele NicoloCharlene Compher
May 21, 2015·The New England Journal of Medicine·Yaseen M ArabiUNKNOWN PermiT Trial Group
Feb 7, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Kailun WangJohn A Windsor
Jul 6, 2016·Journal of Intensive Care Medicine·Cristian MerchanDavid Schwartz
Apr 8, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Juan B Ochoa GautierStephen A McClave
Mar 6, 2018·Therapeutics and Clinical Risk Management·Ayse Gulsah AtaseverEvren Senturk
Oct 23, 2018·The New England Journal of Medicine·UNKNOWN TARGET Investigators, for the ANZICS Clinical Trials GroupPaul Young
Oct 24, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Pierre SingerStephan C Bischoff

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Clinical Trials Mentioned

NCT02806427

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PermiT
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