Meeting current musculoskeletal health demand through deeper insights into tissue homeostasis and regeneration

Expert Opinion on Biological Therapy
Isabel Andia, Nicola Maffulli

Abstract

The burden of chronic musculoskeletal disorders is challenging and prompts therapeutic advancements. The notion that chronic conditions such as osteoarthritis and tendinopathy are linked to deficient healing by failure of one or several of the cellular/molecular processes involved is gaining ground. Alterations underpinning disruption of healing mechanisms that contribute to the development of chronic musculoskeletal pathologies include unresolved inflammation, abnormal angiogenic status, alterations in paracrine communication, decline in stem cell functioning and inability to maintain homeostasis in the extracellular matrix compartment. The complexity of failed healing may be challenged with interventions that target multiple biological processes such as cell therapies and/or platelet-rich plasma.

References

Aug 14, 2008·Current Opinion in Rheumatology·Carla R ScanzelloMary K Crow
Jul 3, 2010·The American Journal of Sports Medicine·Neal L MillarIain B McInnes
Aug 20, 2010·Expert Opinion on Biological Therapy·Isabel AndiaNicola Maffulli
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Nov 18, 2011·Expert Opinion on Therapeutic Targets·Jan Bondeson
Dec 17, 2011·Expert Opinion on Biological Therapy·Isabel AndiaNicola Maffulli
Dec 1, 2012·Osteoarthritis and Cartilage·F Berenbaum
Dec 4, 2012·Arthritis Care & Research·Elena LosinaJeffrey N Katz
Jan 25, 2013·The Journal of Bone and Joint Surgery. American Volume·Alexander M WeinsteinElena Losina
Mar 9, 2013·Tissue Engineering. Part a·Sumit MurabSourabh Ghosh
May 18, 2013·Transplantation·Lluis OrozcoJavier García-Sancho
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Oct 2, 2013·Nature Reviews. Rheumatology·Isabel Andia, Nicola Maffulli
Nov 30, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Keng Lin WongJames H P Hui
Aug 8, 2014·Nature Medicine·Stuart J Forbes, Nadia Rosenthal

❮ Previous
Next ❯

Citations

Apr 4, 2016·Journal of Tissue Viability·Elena Perez-ZabalaIsabel Andia
Jan 5, 2018·Expert Opinion on Biological Therapy·Isabel AndiaNicola Maffulli
Jun 23, 2017·Tissue Engineering and Regenerative Medicine·Arantza InfanteIsabel Andia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Science Translational Medicine
Sabine A EmingMarjana Tomic-Canic
Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine
Robert McCormack
JAMA : the Journal of the American Medical Association
David RabagoAleksandra Zgierska
JAMA : the Journal of the American Medical Association
Leon Creaney
© 2021 Meta ULC. All rights reserved