Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo

Antiviral Research
Hussin A RothanRohana Yusof

Abstract

Chikungunya virus (CHIKV) infection is a persistent problem worldwide due to efficient adaptation of the viral vectors, Aedes aegypti and Aedes albopictus mosquitoes. Therefore, the absence of effective anti-CHIKV drugs to combat chikungunya outbreaks often leads to a significant impact on public health care. In this study, we investigated the antiviral activity of drugs that are used to alleviate infection symptoms, namely, the non-steroidal anti-inflammatory drugs (NSAIDs), on the premise that active compounds with potential antiviral and anti-inflammatory activities could be directly subjected for human use to treat CHIKV infections. Amongst the various NSAID compounds, Mefenamic acid (MEFE) and Meclofenamic acid (MECLO) showed considerable antiviral activity against viral replication individually or in combination with the common antiviral drug, Ribavirin (RIBA). The 50% effective concentration (EC50) was estimated to be 13 μM for MEFE, 18 μM for MECLO and 10 μM for RIBA, while MEFE + RIBA (1:1) exhibited an EC50 of 3 μM, and MECLO + RIBA (1:1) was 5 μM. Because MEFE is commercially available and its synthesis is easier compared with MECLO, MEFE was selected for further in vivo antiviral activity analysis. Treatment with ME...Continue Reading

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Citations

Sep 1, 2016·Antiviral Research·Szu-Cheng KuoChang-Chi Lin
Dec 2, 2017·Viruses·Vaishnavi K GanesanSt Patrick Reid
May 13, 2018·Viruses·Bharat Bhusan SubudhiAbhishek Kumar
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Jan 16, 2020·Current Pharmaceutical Design·Branka PetkovićVesna Pešić
Aug 20, 2019·Antiviral Research·Hussin A RothanShengyun Fang
Mar 31, 2021·Journal of Biomolecular Structure & Dynamics·Durgesh KumarPrashant Singh
Aug 2, 2017·Biochemical and Biophysical Research Communications·Jeng-Wei LuYi-Jung Ho
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Aug 11, 2021·Viruses·Verena BattistiThierry Langer
Jul 16, 2021·Frontiers in Microbiology·UNKNOWN Translational Research Consortia (TRC) for Chikungunya Virus in India

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