Abstract
Chikungunya virus (CHIKV) infection is a persistent problem worldwide due to efficient adaptation of the viral vectors, Aedes aegypti and Aedes albopictus mosquitoes. Therefore, the absence of effective anti-CHIKV drugs to combat chikungunya outbreaks often leads to a significant impact on public health care. In this study, we investigated the antiviral activity of drugs that are used to alleviate infection symptoms, namely, the non-steroidal anti-inflammatory drugs (NSAIDs), on the premise that active compounds with potential antiviral and anti-inflammatory activities could be directly subjected for human use to treat CHIKV infections. Amongst the various NSAID compounds, Mefenamic acid (MEFE) and Meclofenamic acid (MECLO) showed considerable antiviral activity against viral replication individually or in combination with the common antiviral drug, Ribavirin (RIBA). The 50% effective concentration (EC50) was estimated to be 13 μM for MEFE, 18 μM for MECLO and 10 μM for RIBA, while MEFE + RIBA (1:1) exhibited an EC50 of 3 μM, and MECLO + RIBA (1:1) was 5 μM. Because MEFE is commercially available and its synthesis is easier compared with MECLO, MEFE was selected for further in vivo antiviral activity analysis. Treatment with ME...Continue Reading
References
Jul 24, 2001·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M VietriG M Pacific
Oct 3, 2001·Journal of Virology·A M PowersS C Weaver
Feb 9, 2005·Transplantation·Thierry BizollonChristian Trepo
Jan 13, 2006·Structure·Suchetana MukhopadhyayMichael G Rossmann
Jul 28, 2006·The Lancet Infectious Diseases·Paul ReiterChristophe Paupy
Apr 24, 2007·The Lancet Infectious Diseases·Gilles PialouxMichel Strobel
Jun 15, 2007·PloS One·Simona OzdenPierre-Emmanuel Ceccaldi
Jul 3, 2007·PLoS Pathogens·Marion SourisseauOlivier Schwartz
Nov 15, 2007·PloS One·Marie VazeilleAnna-Bella Failloux
Dec 7, 2007·Lancet·Jean-Paul Chretien, Kenneth J Linthicum
Dec 7, 2007·Lancet·G RezzaUNKNOWN CHIKV study group
Dec 12, 2007·PLoS Pathogens·Konstantin A TsetsarkinStephen Higgs
Mar 11, 2008·International Journal of Pharmaceutics·H JeulinV Venard
May 20, 2008·Journal of Hepatology·Eric LawitzJohn G McHutchison
Aug 6, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sebastian DarrAlbert Heim
Aug 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Erin StaplesAnn M Powers
Feb 25, 2010·The Journal of Clinical Investigation·Karine LabadiePierre Roques
Jun 17, 2010·Nature Reviews. Microbiology·Olivier Schwartz, Matthew L Albert
Mar 6, 2012·EMBO Molecular Medicine·Yiu-Wing KamLisa F P Ng
Aug 14, 2012·Virology·Hui-Wen YaoShun-Hua Chen
Oct 2, 2013·Journal of Medicinal Chemistry·Adel A RashadPaul A Keller
Jun 7, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Jie FengJingyan Zhang
Citations
Sep 1, 2016·Antiviral Research·Szu-Cheng KuoChang-Chi Lin
Dec 2, 2017·Viruses·Vaishnavi K GanesanSt Patrick Reid
May 13, 2018·Viruses·Bharat Bhusan SubudhiAbhishek Kumar
Jun 24, 2020·Frontiers in Immunology·Adnan Shah
Jul 31, 2019·Scientific Reports·Jingjing RuanShengyun Fang
Feb 23, 2020·Virus Genes·J J BugertA Brancale
Jan 16, 2020·Current Pharmaceutical Design·Branka PetkovićVesna Pešić
Aug 20, 2019·Antiviral Research·Hussin A RothanShengyun Fang
Feb 14, 2021·Antioxidants·Anna M Fratta PasiniChiara Mozzini
Mar 31, 2021·Journal of Biomolecular Structure & Dynamics·Durgesh KumarPrashant Singh
Aug 2, 2017·Biochemical and Biophysical Research Communications·Jeng-Wei LuYi-Jung Ho
Aug 3, 2021·Molecular Systems Biology·Fangyuan ChenIvet Bahar
Aug 11, 2021·Viruses·Verena BattistiThierry Langer
Jul 16, 2021·Frontiers in Microbiology·UNKNOWN Translational Research Consortia (TRC) for Chikungunya Virus in India