PMID: 8146390Jul 1, 1993Paper

Mefloquine chemoprophylaxis of malaria in the Brazilian Amazonia

Revista Da Sociedade Brasileira De Medicina Tropical
J B SantosE Wanssa


In a randomised double-blind study 122 volunteers living in an endemic malarious area in Amazonian Rondônia state were divided into 4 groups to study malaria suppression. . The first group received 500 mg of mefloquine every month, group II 250 mg every two weeks, group III a tablet of Fansidar (500 mg sulphadoxine + 25mg pyrimethamine) a week and group IV placebo. Acute attacks of malaria occurred in one individual in group I, 2 subject in group II, and 6 individuals in groups III and IV. Protection with mefloquine was significant compared with the placebo group. Both treatment regimens with mefloquine were effective suppressants in an area of high prevalence of drug multiresistant Plasmodium falciparum transmission.


Dec 1, 1977·Annals of Tropical Medicine and Parasitology·W PetersB L Robinson
Mar 1, 1976·Antimicrobial Agents and Chemotherapy·D F ClydeR B Hornick
Sep 29, 1990·Lancet·E PetersenF T Black
Mar 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Björkman, P A Phillips-Howard
Oct 28, 1989·BMJ : British Medical Journal·A Breckenridge
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·J J KarwackiG D Shanks
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·P G KremsnerW H Wernsdorfer
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·V A KilimaliW L Kilama
Sep 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MaynadiéL Yarzabal
Oct 1, 1988·Revista Da Sociedade Brasileira De Medicina Tropical·J B Santos, A Prata
Oct 1, 1987·Annals of Tropical Medicine and Parasitology·H M Gilles
Dec 15, 1984·Experientia·D Stürchler

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Dec 10, 2013·The Cochrane Database of Systematic Reviews·Eugenie PoirotJimee Hwang
Feb 7, 2008·The Cochrane Database of Systematic Reviews·A M J Croft, P Garner
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