PMID: 8146390Jul 1, 1993Paper

Mefloquine chemoprophylaxis of malaria in the Brazilian Amazonia

Revista Da Sociedade Brasileira De Medicina Tropical
J B SantosE Wanssa

Abstract

In a randomised double-blind study 122 volunteers living in an endemic malarious area in Amazonian Rondônia state were divided into 4 groups to study malaria suppression. . The first group received 500 mg of mefloquine every month, group II 250 mg every two weeks, group III a tablet of Fansidar (500 mg sulphadoxine + 25mg pyrimethamine) a week and group IV placebo. Acute attacks of malaria occurred in one individual in group I, 2 subject in group II, and 6 individuals in groups III and IV. Protection with mefloquine was significant compared with the placebo group. Both treatment regimens with mefloquine were effective suppressants in an area of high prevalence of drug multiresistant Plasmodium falciparum transmission.

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Citations

Dec 10, 2013·The Cochrane Database of Systematic Reviews·Eugenie PoirotJimee Hwang
Feb 7, 2008·The Cochrane Database of Systematic Reviews·A M J Croft, P Garner
Oct 31, 2017·The Cochrane Database of Systematic Reviews·Maya Tickell-PainterDavid Sinclair

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