Mefloquine in combination with hemin causes severe damage to adult Schistosoma japonicum in vitro

Acta Tropica
Shu-Hua XiaoLili Wang

Abstract

In order to explore the interaction of mefloquine with hemin against adult Schistosoma japonicum in vitro, the 50% and 95% lethal concentration (LC50 and LC95) of mefloquine and hemin against schistosomes, some factors, such as other iron providing agents, iron chelaters, zinc protoporphyrin-IX, and biological relevant reductants, that might impact on antischistosomal activity induced by interaction of mefloquine with hemin, and preliminary analysis of chemical interaction of both compounds were undertaken. The LC50 and LC95 of mefloquine and hemin alone against schistosomes were determined to be 6.5μg/ml and 7.8μg/ml as well as 232μg/ml and 355μg/ml, respectively. The LC50 and LC95 of mefloquine in the presence of hemin 100μg/ml was 0.24μg/ml and 0.59μg/ml, respectively. On the other hand the LC50 and LC95 of hemin in the presence of mefloquine 1μg/ml was 23.2μg/ml and 77.2μg/ml, respectively. Meanwhile, mefloquine/hemin combinations showed potential synergistic effects against adult S. japonicum, with combination index (CI) values <1. Apart from hemin, zinc protoporphyrin-IX, and other iron providing agents such as ferrous sulfate and ferriammonium sulfate combined with mefloquine exhibited no toxic effect against schistosome...Continue Reading

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Citations

Dec 15, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Fatma E A Bayaumy, Atef S Darwish
Nov 20, 2014·Toxicology Mechanisms and Methods·Mai Helmy El-Dakdoky
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Dec 22, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Ehssan Ahmed HassanMaha Farid Mohamed Soliman

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