PMID: 1304698Dec 1, 1992Paper

Mefloquine-sulphadoxine-pyrimethamine (Fansimef, Roche) in the prophylaxis of Plasmodium falciparum malaria: a double-blind, comparative, placebo-controlled study

Annals of Tropical Medicine and Parasitology
L A SalakoU Dickschat

Abstract

From July 1987 to June 1988 a randomized, double-blind, comparative placebo-controlled field trial was conducted in a group of villages near Ibadan, Nigeria. The aim of the study was to assess the suppressive tolerability and efficacy of four antimalarials (Fansimef, Lariam, Fansidar, chloroquine) given for 24 weeks. Fansimef and Lariam were given with loading and maintenance doses, Fansidar and chloroquine as one tablet per week for 24 weeks. Of 567 enrolled subjects, 114 (20%) had parasitaemia on entry. Eight episodes of symptomatic falciparum malaria occurred during the trial, seven in the placebo group, and one in the Fansimef group. Compared with placebo, parasitaemia was effectively suppressed by all four drug regimens. Adverse event data were not significantly different between groups: six adverse events per 114 participants in the Fansimef group, six/113 in the mefloquine group, five/111 in the Fansidar group, 17/115 in the chloroquine group and eight/114 in the placebo group. Safety of Fansimef for 24 weeks in endemic areas was comparable for standard antimalarials in this trial and provides support for the use of this drug for the treatment of resistant malaria in indigenous African populations.

References

Nov 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SowunmiO A Ogundahunsi
Jul 22, 1989·Lancet·A SowunmiL A Salako
Apr 1, 1989·Annals of Internal Medicine·B RouveixJ L Vienne
Oct 1, 1986·Annals of Tropical Medicine and Parasitology·A D Harries, K S Chugh
May 1, 1986·The American Journal of Tropical Medicine and Hygiene·K D MillerC C Campbell
Jul 1, 1986·The Journal of Infection·M G BamberR A Minns

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Citations

Oct 31, 2017·The Cochrane Database of Systematic Reviews·Maya Tickell-PainterDavid Sinclair
Jan 15, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·W Robert J Taylor, Nicholas J White
Oct 2, 2015·Journal of Travel Medicine·Andrew G TerrellDavid A Ross
Feb 7, 2008·The Cochrane Database of Systematic Reviews·A M J Croft, P Garner

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