Megalospermatocytes in the human testis exhibit asynapsis of chromosomes

Andrologia
R JohannissonA F Holstein

Abstract

Testis biopsies of three infertile patients were identified, which showed a predomination of megalospermatocytes in the seminiferous tubules. Megalospermatocytes are very large primary spermatocytes indicating a spermatogenic arrest. Because of the high percentage of these germ cells it was possible to apply a whole-mount spreading technique to investigate the chromosomal pairing behaviour in prophase I of meiosis. It could be shown that most of the megalospermatocytes exhibited extensive chromosomal asynapsis, suggesting that a characteristic meiotic disorder may give rise to reduced fertility, or even infertility.

References

Jun 1, 1987·Journal of Medical Genetics·A C ChandleyT B Hargreave
Nov 1, 1986·Andrologia·A F Holstein, C Eckmann
Jun 1, 1981·Journal of Ultrastructure Research·T Holstein
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Mar 21, 1997·Mutation Research·R Johannisson, H Ocker
Jan 8, 2000·Results and Problems in Cell Differentiation·T Ashley
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N PezziJ L Barbero

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Citations

Dec 4, 2004·Human Genetics·Fei SunRenée H Martin
Nov 18, 2003·Reproductive Biology and Endocrinology : RB&E·Adolf-Friedrich HolsteinMichail Davidoff
Sep 30, 2005·Cytogenetic and Genome Research·J EgozcueF Vidal
Feb 13, 2014·Experimental and Therapeutic Medicine·Bao-Guo XieWei-Jie Zhu

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