Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata.

Cellular and Molecular Life Sciences : CMLS
Agnès ThierryGuy-Franck Richard

Abstract

Megasatellites are DNA tandem arrays made of large motifs; they were discovered in the yeast Candida glabrata. They are widespread in this species (40 copies) but are not found in any other hemiascomycete so far, raising the intriguing question of their origin. They are found mainly in genes encoding cell wall products, suggesting that megasatellites were selected for a function linked to cell-cell adhesion or to pathogenicity. Their putative role in promoting genome rearrangements by interfering with DNA replication will also be discussed.

References

Mar 21, 1998·Genomics·J E Haber, E J Louis
Dec 29, 1998·Trends in Genetics : TIG·G R SutherlandR I Richards
Mar 21, 2002·The American Journal of Medicine·Gerald P BodeyIssam I Raad
Mar 15, 2003·Cancer Letters·Nicholas C Popescu
Jan 30, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M A PfallerUNKNOWN International Fungal Surveillance Participant Group
Apr 20, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Issam RaadGerald P Bodey
Jul 2, 2004·Nature·Bernard DujonJean-Luc Souciet
Dec 1, 2004·Annual Review of Genetics·Angela TaddeiSusan M Gasser
Dec 24, 2004·Molecular Biology and Evolution·Emmanuelle FabreCécile Fairhead
Feb 3, 2005·Molecular Microbiology·Irene CastañoBrendan P Cormack
Aug 9, 2005·Nature Genetics·Kevin J VerstrepenGerald R Fink
Sep 24, 2005·Molecular Biology and Evolution·Guy-Franck Richard, Bernard Dujon
Oct 26, 2005·Human Molecular Genetics·Thomas W GloverSandra G Durkin
May 30, 2006·Trends in Genetics : TIG·Bernard Dujon
Jul 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Manuel FidalgoJuan Jimenez
Jun 15, 2007·Human Molecular Genetics·Kim Debacker, R Frank Kooy
Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sandra G DurkinThomas W Glover
Apr 9, 2008·Molecular Microbiology·Margaret L ZupancicBrendan P Cormack
Dec 5, 2008·Microbiology and Molecular Biology Reviews : MMBR·Guy-Franck RichardBernard Dujon
Dec 17, 2008·Fungal Genetics and Biology : FG & B·Héloïse MullerCécile Fairhead
Feb 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Silvia PolákováJure Piskur

❮ Previous
Next ❯

Citations

Apr 3, 2010·Nucleic Acids Research·Thomas RollandGuy-Franck Richard
Feb 12, 2013·Eukaryotic Cell·Piet W J de GrootNeeraj Chauhan
Feb 6, 2014·Molecular Biology and Evolution·Elke SchaperMaria Anisimova
May 17, 2015·FEMS Yeast Research·Luis A Vale-Silva, Dominique Sanglard
Jan 11, 2012·Fungal Genetics and Biology : FG & B·Piet W J de Groot, Bernd W Brandt
Sep 4, 2015·BMC Biology·Stéphane Descorps-DeclèreGuy-Franck Richard
May 23, 2018·Journal of Fungi·Bea TimmermansPatrick Van Dijck
Dec 7, 2021·Frontiers in Cellular and Infection Microbiology·Jordan Fernández-PereiraPiet W J de Groot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.