PMID: 9167760Jun 1, 1997Paper

Megestrol acetate in the treatment of hormone refractory prostate cancer

American Journal of Clinical Oncology
J L OsbornD L Trump

Abstract

This retrospective study evaluates the efficacy of megestrol acetate in patients with hormone refractory metastatic adenocarcinoma of the prostate. Data are presented from 14 patients with advanced prostatic adenocarcinoma who were treated with 160-320 mg of megestrol acetate daily. Each patient was either asymptomatic or had minimal cancer-related symptoms. Disease response was monitored by prostate-specific antigen levels. The response rate was 14%, with two patients having a partial response. No complete responses were observed. The median time to disease progression was 2 months. Our findings when considered together with results from previously published data demonstrate little activity of megestrol acetate in patients with hormone refractory prostate cancer. Therefore, we cannot recommend megestrol acetate as an effective second-line therapy.

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Citations

May 21, 2003·Current Urology Reports·Donald Trump, Yiu-Keung Lau
Jun 27, 2002·Current Urology Reports·K A Harris, E J Small
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B Tombal
Feb 28, 2001·Expert Opinion on Investigational Drugs·K A Harris, E J Small
Nov 7, 2006·The Journal of Urology·Eric J Small, Charles J Ryan
Jun 11, 1999·The Urologic Clinics of North America·D M Reese, E J Small
Feb 9, 2000·Radiologic Clinics of North America·E J Small, D M Reese
Apr 11, 2003·The Journal of Urology·Wassim KassoufArmen G Aprikian
Sep 27, 2003·British Journal of Haematology·Stephanie GuyomardNicole Fabien

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